琥珀酸美托洛尔HPMC骨架片释放影响因素研究

以羟丙基甲基纤维素（HPMC）为骨架材料，乙基纤维素（EC）为阻滞剂，采用湿颗粒压片法制备琥珀酸美托洛尔亲水凝胶骨架片，考察HPMC用量、HPMC黏度、EC用量、制备方法、压片压力、释放介质及转速对琥珀酸美托洛尔（MS）骨架片体外释药的影响。结果表明，MS骨架片体外释药符合Higuchi方程，药物释放机制是骨架溶蚀和药物扩散的综合效应；HPMC用量与黏度、阻滞剂用量、制备方法、压片压力对释放速率均有显著性影响；释放介质的pH值及转速对释放速率无显著性影响。

The Factors Influencing Metoprolol Succinate Release from Hydroxypropyl Methylcellulose Matrix Tablet

The hydroxypropyl methylcellulose(HPMC) matrix tablet containing metoprolol succinate(MS) as a model drug was obtained by wet method compression tablet.The effects of the amount and viscosity of HPMC,the preparation method,compressing pressure,the amount of ethycellulose(EC),the pH of dissolution medium and the speed of basket rotation on the drug release from the matrix tablets were evaluated.The results showed that the release rate of metoprolol succinate from HPMC matrix tablets followed Higuchi equation. The release mechanism was in line with the synthetical effect of diffusion and corrosion.Drug release was influenced by the amount and viscosity of HPMC, the amount of EC in matrices,the preparation method and compressing pressure,etc.Drug release was not influenced by the pH of dissolution medium used,and not by the speed of basket rotation,either.