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| CAG方案治疗急性髓系白血病临床分析 | |
| 引用本文： | 周凡,;刘景华,;雷畅,;白颖,;王吉刚,;刘彦琴,;郭步云,;吴丹彤. CAG方案治疗急性髓系白血病临床分析[J]. 解放军医学高等专科学校学报, 2008, 0(3): 393-394 |
| 作者姓名： | 周凡, 刘景华, 雷畅, 白颖, 王吉刚, 刘彦琴, 郭步云, 吴丹彤 |
| 作者单位： | [1]解放军沈阳军区总医院血液科,辽宁沈阳110016; [2]解放军山东省军区门诊部,山东济南250013 |
| 摘 要： | 目的探讨CAG方案对急性髓系白血病治疗的疗效。方法对12例急性髓系白血病住院患者，采用阿糖胞苷和阿克拉霉素联合粒细胞集落刺激因子（CAG）方案治疗，随访其疗效。结果CAG方案对急性髓系白血病的总有效率为75％，完全缓解（CR）率50％，部分缓解（PR）率25％，达CR者中中位生存期和无病生存期为13个月和8个月，PR和未缓解（NR）者中中位生存期分别为6个月和4个月。主要毒副作用是骨髓抑制，其他非血液学毒性表现轻微。结论CAG方案对急性髓系白血病患者有积极的治疗作用，副作用少，值得推广。 |
| 关 键 词： | 白血病 髓系 急性 药物疗法 CAG |
Clinical Analysis of CAG Regimen in Acute Myeloid Leukemia |
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| Affiliation: | Zhou Fan , Liu Jing-hua , Lei Chang , Bai Ying , Wang Ji-gang , Liu Yan-qin , Guo Bu-yun , Wu Dan-tong( Department of Hematology, General Hospital of Shenyang Military Region, PLA, Shenyang 110016, China ; Department of Outpation, PLA Shandong Province Military, Jinan 250013, China) |
| Abstract: | Objective To investigate the efficacy of chemotherapy with CAG （ cytarabine, aclarubicin and granalocyte colony-stimulating factor） regimen to patients with acute myeloid 1 eukemia （AML）. Methods The patients with AML （ n = 12） were treated with CAG regimen and followed up for a long time. Results The response rates were respectively 75% （total efficacy）, 50% [ complete remission （CR） ] and 25% [ partial remission （PR） ] in the patients treated with CAG regimen. The durations of media survival and disease - free survival were 13 and 8 months in CR patients, and the duration of median survival were.6 month in PR patients and 4 months in NR （no remission） patients. Bone marrow suppression was the most common side effect, and other reaction related to nonhematologic toxicity was mild. Conclusion CAG regmen is effective on patients with AML and is worth spreading due to few side effects. |
| Keywords: | leukemia myeloid acute chemotherap CAG |
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