综合干预措施对慢性阻塞性肺病的临床意义

目的探讨综合干预措施对慢性阻塞性肺病的临床价值。方法将100例符合COPD诊断标准的患者随机分成两组。一组采用综合干预措施（包括COPD知识的定期咨询和宣传教育,流感疫苗,肺炎疫苗的接种。同时吸入布地奈德400μg/d,福莫特罗9-18μg/d,及必要的家庭氧疗）。另一组常规处理（对照组）。结果干预组的住院率由干预前19.5%下降至5.5%（P〈0.05）,而对照组则无明显下降。干预组患者急性加重住院时间（11.5±5）d,而对照组则为（20.4±3）d,两组相比差异有统计学意义（P〈0.05）。干预组戒烟40例（80%）,对照组只有10例（20%）,两组比较有统计学差异（P〈0.05）。干预组生活质量评分低于对照组,两组比较差异有统计学意义（P〈0.05）。结论对COPD患者进行综合干预有重要临床意义。

Study on Value of Systemic Intervention in Stable Chronic Obstructive Pulmonary Disease

Objective To improve the quality of life and to decrease the frequency of acute exacerbation in the patients with chronic obstructive pulmonary disease （COPD）. Methods Clinical data of 100 patients, who met the requirements as indicated in the guidelines of COPD published by Respiratory Division of Chinese Medical Association, were collected and divided into two groups at random. One group （trial group ） was administered systemic intervention, including COPD education, pneumonia vaccine injection, direct instruction and consultation from doctors, inhalation of budesonide （400μg/d） and formuterol （9 - 18μg/d） , and so on, The other group （control group） was given the medication only on the patlents＇baslc demand, and didnt receive systemic intervention. Results There existed a group difference in smoking abstinence rate： 80% in the trial group and 20% in the control group （ P 〈 0.05 ）. The frequency of acute exacerbation decreased in the trial group and its hospitalization rate went down from 19.5% （ before intervention） to 5, 5% （ P 〈 0.05 ）. The group difference was also manifested in hospital stay length （ 11.5 ± 5 vs. 20.4± 3 days, P 〈 0.05 ）. The quality of life was significantly improved in the trial group as compared with that in the control group （ P 〈 0.05）. Conclusion Systemic intervention is of importance for the patients with COPD.