| 大黄多糖对脑损伤后大鼠脑皮层热休克蛋白70表达的影响 |
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| 引用本文： | 王志鹏,刘莉,梅其炳,张蓉,顾建文,高大宽,章翔. 大黄多糖对脑损伤后大鼠脑皮层热休克蛋白70表达的影响[J]. 中国组织工程研究与临床康复, 2002, 6(22): 3434-3435 |
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| 作者姓名： | 王志鹏 刘莉 梅其炳 张蓉 顾建文 高大宽 章翔 |
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| 作者单位： | 1. 解放军第四军医大学基础部药理学教研室,陕西西安,710032
2. 解放军第四军医大学西京医院,陕西西安,710032 |
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| 基金项目： | 国家自然科学基金资助项目(3000224) |
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| 摘 要： | 目的观察大黄多糖(TanguticumMaximpolysaccharides,TMP)对大鼠脑损伤后不同时间热休克蛋白(heatshockprotein,HSP)70表达的影响,探讨大黄多糖的脑保护作用机制,为其用于临床治疗脑损伤寻求依据。方法复制大鼠脑挫裂伤模型,分别在伤后6,24,48h以免疫组织化学方法检测大脑皮层表达HSP70的神经细胞,以Western-blot蛋白印迹方法检测脑皮层HSP70表达变化。结果大黄多糖治疗组6hHSP70表达高于损伤组,24,48h均低于治疗组。结论大黄多糖能促进HSP70的表达,这可能是其脑保护作用的机制之一。
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| 关 键 词： | 大黄多糖 脑损伤 热休克蛋白70 |
| 文章编号： | 1007-5496(2001)22-3434-02 |
| 修稿时间： | 2002-08-15 |
Effects of Tanguticum Maxim polysacchrides on heat shock protein70 in cerebral contex with traumatic brain injury of rats |
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| WANG ZHI-PENG,LIU LI,MEI QI-BING,et al.. Effects of Tanguticum Maxim polysacchrides on heat shock protein70 in cerebral contex with traumatic brain injury of rats[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2002, 6(22): 3434-3435 |
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| Authors: | WANG ZHI-PENG LIU LI MEI QI-BING et al. |
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| Affiliation: | WANG ZHI-PENG,LIU LI,MEI QI-BING,et al.Fourth Military Medical University,Xi ' an 710032,China |
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| Abstract: | Objective To study effects of Tanguticum Maxim polysaccharides on heat shock prote in70after traumatic brain injury of rats in different phases,and explore the principle of protective effects of brain.Methods Traumatic brain injury models were p roduced,and the cells which expressed HSP70was dete cted by immunohistochemistry after injuries at 6h ,24h and 48h,the changes of HSP70was deter-matinated by Western-blotting.Results The expression of HSP70in treatment groups was higher than injury groups at 6h,lower at 24h and48h.Conclusion Tanguticum Maxim polysacchrides ca n increased expression of HSP70,whi ch suggests that this is one of principals of brain protective effects of rhubarb polysacchrides. |
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| Keywords: | rhubarb polysacchrides traumatic brain injury heat shock proteins70 |
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