ADH1B与ALDH-2基因多态性与中国人群食管癌发病风险的Meta分析

目的探讨中国人乙醇脱氢酶1B(ADH1B)和乙醛脱氢酶-2(ALDH-2)的基因多态性与食管癌发病风险的关系。方法检索中外文数据库,获得有关ADH1B和ALDH-2位点的多态性与食管癌发病风险的病例-对照研究资料,对各位点以及与饮酒的交互作用进行Meta分析,得到合并的OR值及其95%CI。结果等位基因ADH1B*1和ALDH-2*2可增加食管癌的发病风险。基因型ADH1B*1/*2和ADH1B*1/*1的OR值分别为1.24(95%CI 1.10-1.41)和3.05(95%CI 1.94-4.77);基因型ALDH-2*1/*2和ALDH-2*2/*2的OR值分别为1.6(95%CI 1.01-2.03)和0.77(95%CI 0.28-2.09)。在饮酒人群中,与基因型ADH1B*2/*2相比,ADH1B*1/*2+*2/*2的OR=3.13(95%CI 2.17-4.51);与基因型ALDH-2*1/*1相比,ALDH-2*1/*2+*2/*2的OR=4.12(95%CI 1.98-8.56)。结论在中国人群中,等位基因ADH1B*1和ALDH-2*2均能增加食管癌患病的风险,且饮酒可以增加这一风险。

Genetic polymorphisms of ADH1B and ALDH-2 associated with risk of esophageal cancer:a meta-analysis

Objective To investigate the association of genetic polymorphisms of alcohol dehydrogenase-1B(ADH1B) and aldehyde dehydrogenase-2(ALDH-2) with risk of esophageal cancer(EC) in China.Methods A comprehensive search of the database was performed to identify all case-control studies of ADH1B and ALDH-2 polymorphisms associated with esophageal cancer and their interactions with alcohol drinking.Meta-analysis was carried out for calculation of pooled OR value and its corresponding 95% CI.Results The ADH1B*1 and ALDH-2*2 allele were found to be associated to increased risk of EC,with odds ratios(OR) being 1.24(95%CI 1.10-1.41) and 3.05(95%CI 1.94-4.77) for the ADH1B*1/*2 and ADH1B*1/*1,and 1.6(95%CI 1.01-2.03) and 0.77(95%CI 0.28-2.09) for the ALDH-2*1/*2 and ALDH-2*2/*2 respectively.When compared with the ADH1B*2/*2 genotype in drinkers,the ADH1B*1/*2+*2/*2 can increase risk of EC(OR=3.13,95% CI2.17-4.51).ALDH-2*1/*2 +*2/*2 showed an increased risk to EC among drinks compared with the ALDH-2*1/*1 genotype(OR=4.12,95%CI1.98-8.56).Conclusion ADH1B*1 and ALDH-2*2 allele can increase the risk of EC in china,which can be modified by alcohol consumption.