急性肾衰患者NAG动态观察的意义

目的：探讨急性肾衰（ARF）各期尿NAG动态观察对于该病早期预防、治疗、转归的意义。方法：用改良Ma-ruhn's法，对31例ARF患者分组、分其并就轻、重型病例进行尿NAG动态性观察，并与血中BUN、Scr及对照组比较。结果：ARF患者NAG在病程各期均显著升高，阳性率100％，少尿期为对照组的28.9倍，多尿期下降明显达70％，恢复早期仍异常高值，较同期血中BUN、Scr异常改变表现早、升降幅度大、变化快。轻重型患者之间平均尿NAG值有显著性差异。原发病加重或有新的肾损害因素时，尿NAG动态曲线出现新波峰。结论：动态性尿NAG检测在ARF患者的应用较血中BUN、Scr更早期、敏感、准确地反映肾损害程度及病程演变，特异性好。对于ARF的早期诊断，预防，准确损害程度有重要意义。

Dynamic observation of urinary NAG in acute renal failure

Objective:To investigate the significance of dynamic observation of urinary NAG in early prevention,cure and consequence in different period of acute renal failure(ARF).Methods:31 ARF patients were divided into severe and slight groups.The urinary NAG was dynamically observed by improved Ma ruhn's method and compared with BUN,Scr and control group.Results:ARF patients' urinary NAG was obviously increased and the positive rate was 100%.NAG in oliguria period of the course was 28.9 times of control group,and was obviously decreased by 70% in polyuria period.The average urinary NAG was significantly different between severe and slight groups.Conclusion:The application of dynamic urinary NAG in ARF patients can reflect the degree of renal damage earlier,more sensitively and more exactly.