| 依达拉奉对脑缺血再灌注损伤大鼠Bcl-2和Bax表达的作用研究 |
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| 引用本文： | 丁小明,李德水. 依达拉奉对脑缺血再灌注损伤大鼠Bcl-2和Bax表达的作用研究[J]. 四川解剖学杂志, 2011, 19(1): 5-8 |
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| 作者姓名： | 丁小明 李德水 |
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| 作者单位： | 泉州医学高等专科学校,基础医学部,泉州,362000 |
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| 摘 要： | 为了研究依达拉奉抗细胞凋亡的脑保护作用机制,本实验采用依达拉奉对脑缺血再灌注损伤大鼠进行治疗干预,观察大鼠脑组织Bcl-2和Bax的表达。将36只SD大鼠随机分为假手术组、再灌注组、依达拉奉治疗组,再灌注术后24h断头取脑,免疫组织化学和RT-PCR法观察脑组织Bcl-2和Bax表达水平的变化。结果表明,大鼠脑缺血再灌注损伤后,Bcl-2和Bax含量显著增多;与再灌注组相比,依达拉奉治疗组Bcl-2的表达显著上调,Bax表达显著下调,Bcl-2/Bax比值显著升高。上述结果提示,依达拉奉的脑缺血保护作用可能与上调Bcl-2表达及下调Bax的表达有关。
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| 关 键 词： | 依达拉奉 缺血再灌注损伤 Bcl-2 Bax |
The Effects of Edaravone on the Expression of Bcl-2 and Bax in Rats with Focal CerebralIschemia Reperfusion Injury |
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| Ding Xiaoming,Li Deshui. The Effects of Edaravone on the Expression of Bcl-2 and Bax in Rats with Focal CerebralIschemia Reperfusion Injury[J]. Sichuan Journal of Anatomy, 2011, 19(1): 5-8 |
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| Authors: | Ding Xiaoming Li Deshui |
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| Affiliation: | Ding Xiaoming Li Deshui(Department of Human Anatomy,Medical College of Quanzhou,Quanzhou 362000,China) |
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| Abstract: | Objective To observe the effect of edaravone on the expression of Bcl-2 and Bax of focal cerebral in rats with ischemia-reperfusion injury.Methods The cerebral ischemia reperfusion model was induced by temporary middle cerebral artery occlusion.Male adult Sprague-Dawley rats were randomly divided into the sham-operated group,middle cerebral artery occlusion reperfusion injury model group,and edaravone-treated group.Rats were killed to detect the expression of Bcl-2 and Bax by immunohistochemistry and RT-PCR... |
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| Keywords: | Bcl-2 Bax |
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