| 柴油车尾气颗粒物对小鼠胚胎发育不良影响的初步研究 |
| |
| 引用本文： | 叶雯婧,郑铃,李旭冰,王章敬,杨芬.柴油车尾气颗粒物对小鼠胚胎发育不良影响的初步研究[J].海峡预防医学杂志,2011,17(3):10-12,94. |
| |
| 作者姓名： | 叶雯婧 郑铃 李旭冰 王章敬 杨芬 |
| |
| 作者单位： | 1. 福建医科大学公共卫生学院流行病与卫生统计学系,福州,350004
2. 三明职业技术学院妇产科,福建,365000 |
| |
| 基金项目： | 福建省科技厅计划重点项目基金(No.2007Y0017) |
| |
| 摘 要： | 目的 初步探讨柴油车尾气颗粒对胚胎发育的不良影响.方法 从孕鼠妊娠起经腹腔注射从某交通繁华路段收集的柴油车尾气颗粒,按高剂量7.4mg/(kg·d)、低剂量组(4.4/(kg·d)和二甲亚砜对照组进行研究.结果 高剂量组非存活胎鼠发生率(23.8%)和活胎鼠宫内发育迟缓发生率(9.8%)均高于对照组;高低剂量组均出现外...
|
| 关 键 词： | 柴油车尾气颗粒物 小鼠胚胎 胎盘 病理组织学 环境毒理学 |
Preliminary study of adverse effects of diesel exhaust particles on mice embryonic development |
| |
| YE Wen-jing,ZHENG Ling,LI Xu-bing,et al..Preliminary study of adverse effects of diesel exhaust particles on mice embryonic development[J].Strait Journal of Preventive Medicine,2011,17(3):10-12,94. |
| |
| Authors: | YE Wen-jing ZHENG Ling LI Xu-bing |
| |
| Institution: | YE Wen-jing,ZHENG Ling,LI Xu-bing,et al.Department of Epidemiology and Health Statistics,Public Health College of Fujian Medical University,Fuzhou 350004,China. |
| |
| Abstract: | Objective To explore the effects of diesel exhaust particles on mice embryonic development.Methods Pregnant mice were injected intraperitoneally with diesel exhaust particles collected in a busy traffic section at doses of 7.4 mg/（kg·d）（high dose group） and 4.4 mg/（kg·d）（low dose group） and dimethylsulfoxide to the control group.Results The rate of non-viable fetuses（23.8%） and intrauterine growth retardation（IUGR）（9.8%）of live fetal,and they were significantly higher than that in the control group.Live fetal showed external appearance malformation in experiment groups,and normal appearance in the control group.There were pathological injuries in varying degree in two experiment groups.Conclusions Diesel exhaust particles can result in pathological damage to experimental mice to a certain degree,and the rate increasing of intrauterine growth retardation and malformations. |
| |
| Keywords: | Diesel Exhaust Particles Mice Embryo Placenta Histopathology Environmental Toxicology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
