Heparanase activity in alveolar and embryonal rhabdomyosarcoma: implications for tumor invasion |
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| Authors: | Valentina Masola Claudio Maran Evelyne Tassone Angelica Zin Angelo Rosolen Maurizio Onisto |
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| Affiliation: | (1) Department of Experimental Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy;(2) Division of Hematology-Oncology, Department of Paediatrics, University-Hospital of Padova, Via Giustiniani 3, 35128 Padova, Italy |
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| Abstract: | Background Rhabdomyosarcoma (RMS) is a malignant soft tissue sarcoma of childhood including two major histological subtypes, alveolar (ARMS) and embryonal (ERMS) RMS. Like other human malignancies RMS possesses high metastatic potential, more pronounced in ARMS than in ERMS. This feature is influenced by several biological molecules, including soluble factors secreted by tumor cells, such as heparanase (HPSE). HPSE is an endo-β-D-glucuronidase that cleaves heparan sulphate proteoglycans. |
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