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Hypertrophy and hyperplasia of somatostatin-containing D-cells in diabetes. |
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| Authors: | L Orci D Baetens C Rufener M Amherdt M Ravazzola P Studer F Malaisse-Lagae R H Unger |
| Abstract: | Insulin-, glucagon-, and somatostatin-contianing cells, identified by immunofluorescent staining, were quantitated morphometrically in sections of pancreas obtained from diabetic and nondiabetic humans and rats. Both the volume density and number of somatostatin- and glucagon-containing cells were significantly increased in the islets of juvenile-type human diabetics and of streptozotocin diabetic rats. |
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