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Typing of Pseudomonas aeruginosa strains in Norwegian cystic fibrosis patients
Authors:G. Fluge,B. Ojeniyi,N. Hø  iby,A. Digranes,O. Ciofu,E. Hunstad,O. C. Haanaes, O.-T. Storrø  sten
Affiliation:Department of Pediatrics, Haukeland University Hospital, Bergen, Norway,;The Royal Veterinary and Agricultural University, Copenhagen, Denmark,;Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark,;Department of Microbiology and Immunology, Haukeland University Hospital, The Gade Institute, Bergen, Norway and;The Norwegian Cystic Fibrosis Center, Oslo, Norway
Abstract:Objectives   Typing of Pseudomonas aeruginosa isolates from Norwegian cystic fibrosis (CF) patients with chronic Pseudomonas lung infection in order to see whether cross-infection might have occurred.
Methods   Isolates from 60 patients were collected during the years 1994–98, and typed by pulsed field gel electrophoresis.
Results   Seventy-one strains were identified. One large cluster of identical strains included 27 patients, and 13 smaller clusters of 2–4 patients were found (26 patients). Seven patients had a strain not shared by other patients (private strains). Harboring the main cluster strain was significantly associated with participation in summer camps and training courses ( P  = 0.004, chi-squared test). There were no associations with regular admissions to hospital (intravenous antibiotic courses) or smaller social gatherings of short duration. Small clusters and private strains were not associated with any of the risk factors. All strains were sensitive to colistin. The minimal inhibitory concentrations were generally lower in Norwegian P. aeruginosa strains compared with isolates from Danish patients.
Conclusions   Our results indicate that cross-infection with P. aeruginosa between cystic fibrosis patients has occurred.
Keywords:Cystic fibrosis    Pseudomonas aeruginosa    lung infection
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