| 11β-羟基类固醇脱氢酶1与代谢综合征 |
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| 引用本文： | 张爱萍,张木勋. 11β-羟基类固醇脱氢酶1与代谢综合征[J]. 医学综述, 2006, 12(3): 134-136 |
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| 作者姓名： | 张爱萍 张木勋 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院内分泌科,湖北,武汉,430030 |
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| 摘 要： | 11β羟基类固醇脱氢酶1(11βHSD1)在体内主要为还原酶,负责活性的糖皮质激素向其无活性前体的转换,调节局部糖皮质激素浓度,是糖皮质激素受体前调节,并决定糖皮质激素流向其受体而发挥作用。代谢综合征糖皮质激素敏感性增加,11βHSD1调节异常,可能是肥胖、糖耐量低减、高血压和心血管疾病等代谢综合征重要发病机制之一,选择性11βHSD1抑制剂有望成为其治疗靶点。
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| 关 键 词： | 11β-羟基类固醇脱氢酶1 糖皮质激素 代谢综合征 |
| 文章编号： | 1006-2084（2006）03-0134-03 |
| 收稿时间： | 2005-09-12 |
| 修稿时间： | 2005-12-07 |
11β-Hydroxysteroid Dehydrogenase Type 1 and Metabolism Syndnome |
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| ZHANG Ai-ping,ZHANG Mu-xun. 11β-Hydroxysteroid Dehydrogenase Type 1 and Metabolism Syndnome[J]. Medical Recapitulate, 2006, 12(3): 134-136 |
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| Authors: | ZHANG Ai-ping ZHANG Mu-xun |
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| Affiliation: | Department of endocrinology, Tongji Hospital affdiated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Ciha |
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| Abstract: | 11β-hydroxysteroid dehydrogenase type 1(11β-HSD1) mainly conversesinactive-glucocorticoids to active-glucocorticoids in local tissue in vivo,and is served as a pre-receptor regulator to decide glucocorticoid to specialreceptors,then causes effects of hormone in tissues.Increased sensitivity and dis regulation of 11β-HSD1 in metabolism may be one of the important mechanisms of obesity,sugar intolerance,hypertension and cardiovascular diseases,etc.selective inhibit or of 11β-HSD1 will be expected to be an effective therapeutic target. |
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| Keywords: | 11β-hydroxysteroid dehydrogenase type 1 Glucocorticoids Metabolism syndraome |
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