护肝降酶口服液对小鼠急性肝损伤的保护作用

目的：探讨护肝降酶口服液(HGJMKFY)对小鼠急性肝损伤的保护作用。方法：采用四氯化碳(carbontetrachloride,CCl4)、D-半乳糖胺(D-galactosamine,D-GaIN)复制小鼠急性肝损模型。给予护肝降酶口服液(分大、小剂量组),并设联苯双酯阳性对照及空白对照组。测定血清中丙氨酸氨基转移酶(alanineaminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)的水平。结果：护肝降酶口服液36g/kg剂量组对CCl4所致的小鼠急性肝损ALT和AST升高有明显降低作用;其36g/kg和18g/kg剂量组对D-半乳糖胺所致的小鼠急性肝损血清ALT和AST的升高均有明显降低作用。结论：护肝降酶口服液对CCl4、D-GaIN所致小鼠急性肝损伤有一定保护作用。

Experimental Study of Huganjiangmei Oral Liquid in Protection from Acute Liver Injury on Mouse

Objective: To study the protective effect of Huganjiangmei (HGJMK)Oral Liquid in acute liver injury mice. Methods: Mouse model of acute hepatic injury induced by Carler tetrachloride (CCl4) and D galactosamine (D-GalN) was set up and HGJM Oral Liquid with the dose of 18 and 36g/kg was administrated i.g. to mice.The level of ALT and AST in blood serum were measured. Results: 36g/kg dose of HGJM oral liquid could decrease ALT and AST in acute liver injury induced by CCl4-intoxication.18 and 36g/kg dose of HGJM Oral Liquid could decrease ALT and AST in acute liver injury induced by D-GalN. Conclusions: HGJM Oral Liquid can protect the damaged liver in mice.