吸烟与帕金森病关系的病例对照研究

目的　探讨吸烟与帕金森病 (PD)的关系。方法　采用以人群为基础的病例对照研究 ,调查在北京地区 55岁以上PD患病率调查中确诊及 2 0 0 2年 8月至 2 0 0 3年 1月在北京协和医院帕金森研究中心诊治的病例共 1 1 4例 ;以及性别、民族及居住地与其匹配的对照 2 0 5名。结果　吸烟与PD呈显著负相关联。以非吸烟者为对照 ,曾经吸烟者、现在吸烟者和过去吸烟者患PD的危险性低于对照 ,OR值分别为 0 .49(95 %CI:0 .30～ 0 .79)、0 .44(95 %CI :0 .2 3～ 0 .86)和 0 .54(95 %CI:0 .30～0 .96)。此外 ,对吸烟者分别按吸烟年限≥ 2 0年和 <2 0年、戒烟年限≥ 2 0年和 <2 0年以及吸烟量分层和logistic回归分析 ,其负相关联依然存在并具有剂量反应关系的趋势 (P <0 .0 5)。结论　吸烟与PD存在负相关联 ,今后应着重开展有关生物学依据的研究

Cigarette smoking and Parkinson'' s disease: a population based case-control study

Objective To explore the association with cigarette smoking for Parkinson's disease (PD). Methods One hundred and fourteen PD cases and 205 controls matched on gender and race were recruited from ongoing PD prevalence survey and identified at the neurological clinic of Peking Union Medical College Hospital. Face to face questionnaire interview was carried out and data on smoking and alcohol consumption were analyzed in a population based case control study. Results With never smokers as the reference category, we observed reduced risk for PD among ever smokers ( OR = 0.49 ,95% CI : 0.30 0.79 ) current smokers ( OR = 0.44 , 95% CI : 0.23 0.86 ) and ex smokers ( OR = 0.54 ,95% CI : 0.30 0.96 ). When comparing with non smokers, the ever smokers stratified by years of smoking had an inverse association with those whose smoking history longer than 20 years ( OR = 0.35 ,95% CI : 0.18 0.70 ) and an mild protective association with those who smoked less than 20 years ( OR = 0.61 , 95% CI : 0.35 1.07 ). Those who had quitted smoking for more than 20 years were less likely to have the disease than never smokers, and those who had quitted for less than 20 years were least likely to have PD.Those current smokers were still least likely to have the disease. Significant inverse gradient with pack day smoker (trend P < 0.05 ), and the inverse association for cigarette smoking and PD were found not bing confounded by alcohol consumption. Conclusion The inverse association between PD and cigarette smoking and history of cessation was found. Further studies need to provide biochemical evidence on the relation between smoking and its protective effect on PD.