姜黄素对支气管哮喘大鼠气道重塑和核因子-κB的影响

目的:探讨姜黄素对支气管哮喘大鼠气道重塑及核因子-κB(NF-κB)的影响。方法:将Wistar大鼠随机分为对照组、哮喘组、姜黄素组,各10只;采用卵蛋白(OVA)致敏复制大鼠哮喘模型。观察3组大鼠气道炎症、气道壁厚度、胶原沉积及NF-κB和转化生长因子(TGF-β1)表达情况。结果:哮喘组大鼠炎性细胞浸润、胶原沉积、气道壁厚度、NF-κB、TGF-β1表达与对照组比较有显著性差异(P<0.01),而姜黄素组较哮喘组明显减轻(P<0.01);NF-κB与TGF-β1表达、气道炎症、气道壁厚度、胶原沉积变化成正相关(P<0.01)。结论:姜黄素可抑制哮喘大鼠NF-κB活性以干预其气道重塑。

Effects of Curcumin on Airway Remodeling and Nuclear Factor Kappa-B in Asthmas Rats

Objective: To investigate the influence of curcumin on airway remodeling and nuclear factor kappa-B(NF-κB) in rats with asthmas.Methods: Wistar rats were randomly divided into three groups: control group,asthma group and curcumin group,10 rats in each group.Asthma model was duplicated by injecting ovalbumin(OVA).The airway inflammation,thickness,collagen deposit,NF-κB and transformation growth factor beta1(TGF-β1) were observed.Results: There were significant differences in airway inflammation,thickness,collagen deposit,NF-κB and TGF-β1 expressions between control group and asthma group,and between asthma group and curcumin group(P<0.01);NF-κB expression was positively correlated with TGF-β1 expression,airway inflammation,airway thickness and collagen deposition(P<0.01).Conclusion: Curcumin can down-regulate NF-κB expression to suppress airway remodeling in asthma rats.