| 术前短程冲击化疗在进展期胃癌的临床研究 |
| |
| 引用本文： | 刘伟平,夏建国,丁永斌. 术前短程冲击化疗在进展期胃癌的临床研究[J]. 中国医疗前沿, 2008, 3(16): 16-17 |
| |
| 作者姓名： | 刘伟平 夏建国 丁永斌 |
| |
| 作者单位： | 南京医科大学附属第一医院普外科,江苏,南京,210029 |
| |
| 摘 要： | 目的研究术前短程冲击化疗对进展期胃癌肿瘤细胞凋亡的影响。方法2004年6月至2005年4月间,共有28例未经治疗的局部进展期胃癌患者入组本次临床研究。入组病例中随机抽取18例患者行以多帕菲70-75mg/m2,第一天使用,静滴;顺铂20mg/天d1～5天,静滴;5-FU0.75/天,d1～5天,静滴,为主的术前短程冲击化疗方案一个疗程治疗,10例为空白对照组。观察术前短程冲击化疗后原发病灶中肿瘤细胞的凋亡指数,并观察术前短程冲击化疗的毒副反应。结果术前短程冲击化疗后所有病人行根治性手术治疗,术后化疗组肿瘤细胞的凋亡指数明显高于对照组(P<0.01)。毒副反应主要为白细胞减少症,腹泻,恶心呕吐,脱发等,所有18例行术前化疗的患者的白细胞减少症都在0～I级,且所有行术前化疗患者在结束一个疗程的术前短程冲击化疗后均能行正常手术。结论术前短程冲击化疗对进展期胃癌近期疗效显著,能诱导肿瘤细胞凋亡,是一种简便可行安全高效的胃癌治疗方法,且耐受性良好,化疗导致的毒副作用较轻,在结束短程冲击化疗后均能行手术治疗,术后恢复良好。
|
| 关 键 词： | 胃癌 术前化疗 多西紫杉醇 顺铂5-FU 细胞凋亡 |
Clinical investigation of the effect of preoperative short course impact chemotherapy on advanced gastric cancer |
| |
| Liu Wei-pin,DING Yong-bin,XIA Jian-guo. Clinical investigation of the effect of preoperative short course impact chemotherapy on advanced gastric cancer[J]. China Healthcare Innovation, 2008, 3(16): 16-17 |
| |
| Authors: | Liu Wei-pin DING Yong-bin XIA Jian-guo |
| |
| Affiliation: | Liu Wei-pin; DING Yong-bin; XIA Jian-guou (Department of General Surgery; First Affiliated Hospital of Nanjing Medical University; Nanjing 210029; China); |
| |
| Abstract: | Objective To investigate curative and toxic effects of preoperative short course impact chemotherapy on advanced gastric cancer. Methods This study, from June, 2004 to April, 2005, included 28 untreated subjects of local advanced gastric cancer. Of all the cases, 18 were selected randomly to receive one course of preoperative short course impact chemotherapy, in which the subjects were given intravenous injection of Docetaxel 70~75mg/m2 on the first day, Cisplatin 20mg/d for 5 days and 5-FU 0.75g/d for 5 da... |
| |
| Keywords: | Gastric cancer Preoperative chemotherapy Docepaclitaxel Cisplatin 5-FU Cell apoptosis |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
