功能磁共振成像对正常人脑手运动皮质的定位研究

【目的】使用功能磁共振成像(functional magnetic resonance imaging,fMRI)技术对正常人脑手运动皮质进行定位。【方法】健康受试者10人,男7例,女3例,均为右利手,每个健康受试者分别完成左右手运动刺激。刺激模式为手握拳运动。fMRI检查采用Philips 3.0 T超导型磁共振机,GRE-EPI序列。使用SPM5软件进行预处理和统计分析。【结果】10例正常受试者,左手或右手运动时均见对侧初级运动皮质(Primary motor cortex,M1)区激活;同侧M1、辅助运动区(supplementary motor area,SMA)、后顶叶皮层(posterior parietal cortex,PPC)、前额叶皮层(prefrontal cortex,PFC)及小脑存在不同比例、不同程度激活。非利手即左手运动引起右侧M1区激活体积大于利手运动引起的左侧M1区激活体积(P<0.05)。【结论】M1区是控制对侧手运动的脑皮质区,同侧M1、SMA、PPC、PFC及小脑也参与手运动,非利手与利手运动激活对侧M1区的程度存在差异。

Study on the location of motor cortica area of the hand in human by fMRI

[Objective]To locate the motor cortica area of the hand in human. [Methods] 10 healthy subjects（7males and 3 females, right-dominant hand model） were selected in this experiment. Each of the healthy subjects should perform both left and right hand motor excitation. Stimulating patterns for hand were clench fist motion. 3.0 Tesla superconductive MRI system and GRE-EPI technology was used to get fMRI. The results were analyzed by SPM5 software. [Results] The activating cerebral regions of 10 normal subjects （right or left hand moving） were located in contralateral primary motor cortex （M1）. Different proportion and degree of ipsilateral M1, supplementary motor cortex（SMC）, posterior parietal cortex（PPC）, prefrontal cortex（PFC） and bilateral cerebellum were activated. The M1 volume activated by the left hand （non-dominant hand） movemen was greater than that by right hand （dominant hand） . [ Conclusions ] Cerebral cortex area of hand movement lies on the contralateral M 1.The ipsilateral M 1, SMA, PPC, PFC and cerebellum are also involved in hand movement. The M1 volume activated by non-dominant hand movemen is different to that by dominant hand.