胃癌组织中组织蛋白酶D和层黏连蛋白受体的表达及意义

 目的　研究组织蛋白酶D、层黏连蛋白受体在胃癌中的表达，探讨其与胃癌侵袭及淋巴结转移的关系。方法　采用免疫组织化学SP法，检测96例胃腺癌组织中组织蛋白酶D和层黏连蛋白受体的表达情况。结果　组织蛋白酶D在浆膜层、有淋巴结转移及低分化胃癌组织中的表达明显高于浸润肌层以下、无淋巴结转移及高、中分化的胃癌（分别为P＜0.01，P＜0.01，P＜0.05）。经四格表χ2检验，层黏连蛋白受体在胃癌组织中的高表达与浸润深度、分化程度密切相关（分别为P＜0.05和P＜0.01），与淋巴结转移无关（P＞0.05）。胃癌组织中层黏连蛋白受体和组织蛋白酶D之间的相关性分析显示，组织蛋白酶D阳性表达与层黏连蛋白受体阳性表达之间呈正相关（P＜0.05）。结论　胃癌组织中层黏连蛋白受体高表达、组织蛋白酶D高表达与胃癌侵袭转移密切相关。

Expression and significance of Cathepsin D and Laminin receptors in gastric cancers

Objective To investigate the elationship between the expression of Cathepsin D and Laminin receptors with the invasion and metastasis of gastric cancers.Methods Cathepsin D and Laminin receptors immunoreactivities were evaluated in 96 patients with gastric cancer using streptavaclin pemxidase method.Results Over expression of Cathepsin D in gastric cancer tissue was significantly related with the depth of invasion,lymphnode metastasis and grade of differentiation (P<0.01,P<0.01 and P<0.05, respectively).Moreover,the high expression of Lamninin receptors in gastric cancer had significant correlations with the invasion depth and grade of differentiation(P<0.05 and P<0.01);The positive expression of Laminin receptors were not significantly related with lymph node metastasis(P>0.05).By statistics analysis Cathepsin D had a significant positive correlation with Laminin receptors (P<0.05). Conclusion Cathepsin D and Laminin Receptors play all important role in the invasion and metastasis of gastric Cancers.