| The effect of transforming growth factor—β1 on expression of SMAD3 and SMAD7 in keloid—derived fibroblasts |
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| 作者姓名： | 杨力 李荟元 郭树忠 韩岩 汤苏阳 张琳西 舒茂国 潘宝华 |
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| 作者单位： | DepartmentofPlasticSugery,XijingHospital,ForthMilitaryMedicalUniversity,Xi‘an710032,ShaanxiProvince,China |
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| 摘 要： | ![]()
AIM:To study the expression of SMAD3 and SMAD7 of transforming growth factor-β1(TGF-β1)on keloid-derived fibroblasta.METHODS:The expression of SMAD3(at 1,2,4,24,48h) and SMAD7(at 0.51,1.5,2,4,24h) were added to the monolayer culture system.RESULTS:The level of SMAD3 were down regulated at 24h and the SMAD7 were maximum up regulated at 4h when TGF-β1 were used .CONCLUSION:TGF-β1 may down regulate the expression of SMAD3,but up regulate that of SMAD7.
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| 关 键 词： | 转化生长因子βl 瘢痕疙瘩 成纤维细胞 SMAD3.7 表达 影响 |
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