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The cardio-facio-cutaneous syndrome: report of a patient and review of the literature
Authors:A. Bottani  I. Hammerer  A. Schinzel
Affiliation:(1) Institut für Medizinische Genetik der Universität Zürich, Rämistrasse 74, CH-8001 Zürich, Switzerland;(2) Universitäts-Kinderklinik, Anichstrasse 35, A-6020 Innsbruck, Austria
Abstract:
We report a 3-year-old girl with the cardiofacio-cutaneous (CFC) syndrome. She presented the typical combination of mild developmental delay, postnatal onset short stature with relative macrocephaly, a wide and prominent forehead with posteriorly rotated ears and down-slanting palpebral fissures, an atrial septal defect, and ectodermal abnormalities. All cases reported to date occurred sporadically. The actiology remains unknown; de novo mutations of an autosomal dominant gene seem the most likely explanation.
Keywords:Cardio-facio-cutaneous syndrome  Multiple congenital anomalies/mental retardation syndrome  Congenital heart disease  Ectodermal abnormalities  Sporadic occurrence
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