| 艾司唑仑有关物质的HPLC测定法 |
| |
| 引用本文： | 孙红英,李宝国,李军. 艾司唑仑有关物质的HPLC测定法[J]. 齐鲁药事, 2006, 25(11): 660-662 |
| |
| 作者姓名： | 孙红英 李宝国 李军 |
| |
| 作者单位： | 1. 山东省医药工业研究所,济南,250100
2. 山东中医药大学,济南,250014 |
| |
| 摘 要： | 目的建立HPLC法测定艾司唑仑的有关物质。方法采用十八烷基键合硅胶为填充剂,甲醇-水(65∶35)为流动相,检测波长223nm。结果艾司唑仑在1.2~2.8μg.ml-1浓度范围内呈良好的线性关系(r=0.9998),RSD为0.56%。检测限为0.02ng。结论本方法结果准确,可用于艾司唑仑有关物质的控制。
|
| 关 键 词： | 艾司唑仑 有关物质 高效液相色谱法 |
| 文章编号： | 1672-7738(2006)11-0660-03 |
Determination related substances of Estazolam by HPLC |
| |
| SUN Hong-ying,LI Bao-guo,LI Jun. Determination related substances of Estazolam by HPLC[J]. qilu pharmaceutical affairs, 2006, 25(11): 660-662 |
| |
| Authors: | SUN Hong-ying LI Bao-guo LI Jun |
| |
| Abstract: | OBJECTIVE An HPLC method for determination related substances of Estazolam was established.METHODS A C_(18) column was used with the mobile phase of methanol-water(65∶35),the detection wavelength was 223nm.RESULTS The linear range of Estazolam was 1.2～2.8μg·ml~(-1)(r=0.9998),RSD=0.56%.The detection limit was 0.02ng.CONCLUSION The method was accurate,it can be used to determine related substances of Estazolam. |
| |
| Keywords: | Estazolam related substances HPLC |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
