| 表面改性对羟基磷灰石蛋白吸附的影响 |
| |
| 引用本文： | 王岩,肖艳,郎美东.表面改性对羟基磷灰石蛋白吸附的影响[J].医学教育探索,2011(5):565-570. |
| |
| 作者姓名： | 王岩 肖艳 郎美东 |
| |
| 作者单位： | 华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与
应用教育部重点实验室， 上海 200237;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与
应用教育部重点实验室， 上海 200237;华东理工大学材料科学与工程学院， 上海市先进聚合物材料重点实验室，超细材料制备与
应用教育部重点实验室， 上海 200237 |
| |
| 基金项目： | 中央高校基本科研业务费专项资金（WD0913008，WD1014017）;上海市曙光学者计划；上海市自然科学基金(11ZR1409200)；上海市重点学科和重点实验室项目(B502，D8DZ2230500) |
| |
| 摘 要： | 采用原子转移自由基聚合(ATRP)在羟基磷灰石(HAP)纳米粒子表面接枝了聚甲基丙烯酸甲酯(PMMA)。随着接枝的PMMA含量增加，改性粒子在水溶液中的分散性增强。以牛血清白蛋白(BSA)和溶菌酶(LSZ)为吸附目标，研究了HAP和改性后的粒子(gHAP)的蛋白质吸附性能。结果发现，gHAP比HAP对蛋白质的单位吸附量大，表面接枝PMMA可以增加HAP对蛋白质的吸附。
|
| 关 键 词： | 羟基磷灰石 表面改性 分散性 蛋白质吸附 |
Effect of Surface Modification on Protein Adsorption
Characteristics of Hydroxyapatite |
| |
| WANG Yan,XIAO Yan and LANG Mei-dong.Effect of Surface Modification on Protein Adsorption
Characteristics of Hydroxyapatite[J].Researches in Medical Education,2011(5):565-570. |
| |
| Authors: | WANG Yan XIAO Yan and LANG Mei-dong |
| |
| Institution: | Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine
Materials of Ministry of Education, School of Materials Science and Engineering,
East China University of Science and Technology,Shanghai 200237, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine
Materials of Ministry of Education, School of Materials Science and Engineering,
East China University of Science and Technology,Shanghai 200237, China;Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine
Materials of Ministry of Education, School of Materials Science and Engineering,
East China University of Science and Technology,Shanghai 200237, China |
| |
| Abstract: | Hydroxyapatite (HAP) nanoparticles were surface grafted with poly(methyl methacrylate) (PMMA) through atom transfer radical polymerization (ATRP). As the amount of grafted PMMA increased, the dispersibility of surface grafted HAP (g HAP) in aqueous solution was improved. Bovine serum albumin (BSA) and lysozyme (LSZ) were selected as models to study their adsorption behaviors on HAP and g HAP. Our results showed that the adsorption capacity on g HAP was higher than that on HAP, indicating that the adsorptive property of HAP was improved due to surface modification of HAP with PMMA. |
| |
| Keywords: | hydroxyapatite surface modification dispersibility protein adsorption |
|
| 点击此处可从《医学教育探索》浏览原始摘要信息 |
| 点击此处可从《医学教育探索》下载免费的PDF全文 |
