| 经皮自体移植浓缩骨髓干细胞治疗骨不连的实验研究 |
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| 引用本文： | 刘亚云,杨保华,陈光连. 经皮自体移植浓缩骨髓干细胞治疗骨不连的实验研究[J]. 江西医药, 2013, 0(11): 968-970 |
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| 作者姓名： | 刘亚云 杨保华 陈光连 |
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| 作者单位： | [1]江西省人民医院,南昌330006 [2]江西省修水县第一人民医院,修水332400 |
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| 基金项目： | 江西省卫生厅课题（20091021） |
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| 摘 要： | 目的探讨浓缩骨髓干细胞治疗动物骨不连的实验效果。方法制作兔骨不连模型32只。并根据干预方式不同随机均分为两组：干细胞组和内固定植骨术组。定期拍片测量骨折间隙宽度变化（8周、12周）、免疫组化观察。结果两组术后8周、12周X线测定、组织病理切片均形成骨性连接，新骨形成、骨改建及骨髓成熟度指标相当，且两组没有统计学意义（P〉0．05）。结论兔移植自体浓缩的骨髓干细胞参与了骨不连的成骨，有利于骨折的愈合，与自体骨移植效果相当。
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| 关 键 词： | 骨髓基质干细胞 骨髓移植 浓缩 骨不连 |
The experimental study of nonunion treatment with percutaneous autogenous concentrated bone marrow grafting |
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| LIU Yayun,YA NG Baohua,CHEN Guanglian. The experimental study of nonunion treatment with percutaneous autogenous concentrated bone marrow grafting[J]. Jiangxi Medical Journal, 2013, 0(11): 968-970 |
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| Authors: | LIU Yayun YA NG Baohua CHEN Guanglian |
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| Affiliation: | 1. Jiangxi Provincial People＇ s Hospital, Nanchang 330006, China; 2. People＇ s Hospital of Xiushui,Xiushui 332405, China. |
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| Abstract: | Objective To observe the experiental effect of nonunion treatment with percutaneous autogenous concentrated bone marrow grafting. Methods 32 rabbits were used to make nonunion models,they were grouped randomly into two groups（Bone marrow stem cells group,Internal fixationand grafting group）. Periodical standardized radiographs,histology and heal rate after 8weeks and 12weeks were perfoermed. Results The gap changes of bone union at 8weeks and 12weeks after treatment in group A and B,were not statically significant. Conclusion Percutaneous autogenous concentrated bone marrow of the rabbits can induce osteogenesis in bone nonunion,its efficacy appears to be related to the concentration of bone marrow stem cells in the graft. |
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| Keywords: | Bone marrow stem cells（BMSCs） Bone marrow grafting Concentration Nonunion |
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