视网膜Müller细胞的研究进展

Müller细胞是视网膜特化的胶质细胞,它贯穿于视网膜全层,与视网膜神经元、其它胶质细胞、视网膜血管等紧密联系。Müller细胞不但对视网膜正常发育起着决定性作用,而且能支持神经元活动、调节神经递质循环、维持细胞外环境平衡、调节视网膜血管通透性。视网膜Müller细胞代谢障碍将导致视功能丧失、神经元细胞死亡、视网膜水肿等。因此,Müller细胞对维持视网膜的正常生理功能起着重要作用。我们就近年来Müller细胞的研究进展作一综述。

Research advances on retinal Müller cells

Müller cells are the specialized glial cell of the retina.They span the entire thickness of the retina,have a close contact with retinal neurons,other glial cells and retinal blood vessels.Müller cells play a decisive role in the normal development of the retina,and can support neuronal activity,regulate neurotransmitter cycle,maintain homeostasis of the extracellular environment,regulate retinal vascular permeability.Dysmetabolism in retinal Müller cells will result in loss of visual function,neuronal cell death,retinal edema,et al.Therefore,Müller cells play an important role in retinal physiology.This paper reviewed recent Müller cells research.