| 蛋白酪氨酸磷酸酶-1B与2型糖尿病 |
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| 引用本文： | 王淼,邹大进. 蛋白酪氨酸磷酸酶-1B与2型糖尿病[J]. 国际内分泌代谢杂志, 2006, 26(6): 388-390 |
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| 作者姓名： | 王淼 邹大进 |
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| 作者单位： | 200433,上海,第二军医大学长海医院内分泌科 |
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| 摘 要： | 研究证实,蛋白酪氨酸磷酸酶-1B(PTP-1B)主要通过以下几方面参与2型糖尿病的发病(1)可与胰岛素受体及其底物相作用,减弱胰岛素信号转导,引起胰岛素抵抗。(2)参与对胰岛β细胞数量的调节。(3)与瘦素抵抗及脂代谢异常关系密切,由此引发并加重2型糖尿病。目前已合成各种类型的PTP-1B抑制剂,有良好的降糖等疗效,临床应用前景广阔。
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| 关 键 词： | 蛋白酪氨酸磷酸酶-1B 2型糖尿病 胰岛素抵抗 蛋白酪氨酸磷酸酶-1B抑制剂 |
| 收稿时间： | 2005-12-10 |
| 修稿时间： | 2005-12-10 |
Protein tyrosine phosphatase 1B and type 2 diabetes |
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| WANG Miao,ZOU Da-jin. Protein tyrosine phosphatase 1B and type 2 diabetes[J]. International JOurnal of Endocrinology and Metabolism, 2006, 26(6): 388-390 |
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| Authors: | WANG Miao ZOU Da-jin |
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| Affiliation: | Department of Endocrinology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China |
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| Abstract: | Protein tyrosine phosphatase 1B(PTP-1B) is proved to contribute to the pathogenesis of type 2 diabetes through the following ways:(1)PTP-1B is associated with insulin receptor and down regulates insulin signaling which causes insulin resistance. (2) PTP-1B participates in the regulation of pancreas beta cells mass. (3) PTP-1B may play a role in leptin resistance and lipid metabolism disorder. All of this promote the pathogenesis and development of type 2 diabetes. Several kinds of PTP-1B inhibitors have been synthetized which can normalize hyperglycaemia, and have spacious prospect of clinical application. |
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| Keywords: | Protein tyrosine phosphatase 1B Type 2 diabetes Insulin resistance Protein tyrosine phosphatase 1B inhibitor |
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