载脂蛋白E基因多态性与自杀未遂关系的研究

目的探讨载脂蛋白E(Apo E)基因多态性与自杀未遂的关系。方法采用配对病例对照与聚合酶链反应和限制性片段长度多态性(PCR-RFLP)方法对220对自杀未遂者及对照进行分析。结果自杀未遂者中存在ApoE4种基因型,分别为Apo E-E2/3,E3/3,E2/4和E3/4,其中以Apo E-E3/3为主。经多状态模型分析影响不同基因型自杀未遂(Apo E-E2/3、E3/3、E2/4均相对于E3/4基因型)的因素,发现情感冲突、对现在生活不满意与E2/4基因型相关,情感冲突与E2/3基因型相关,没有发现与E3/3型相关的因素。经条件Logistic回归模型分析未发现不同Apo E基因型与自杀未遂相关联。结论本研究不支持Apo E基因与自杀未遂相关联,但不同Apo E基因型自杀未遂的影响因素不同。

Study on association between gene polymorphism of Apolipoprotein E and attempted suicide

Objective To understand the association between gene polymorphism of apolipoprotein E(Apo E)and attempted suicide.Methods 220 paired suicide attempted and controls were analyzed by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP).Results There were four gene types of Apo E in each suicide attempters and controls group which were Apo E-E2/3,E3/3,E2/4 and E3/4 and in which Apo E-E3/3 was the main type.Multinomial model was used to analyze the factors which were related with attempted suicide with different Apo E gene type(attempters with Apo E-E3/4 being reference group),the results showed that affective conflict and dissatisfaction with life now were associated with attempters with Apo E-E3/3,affective conflict were also associated with attempters with Apo E-E2/3,and no factors were associated with attempters with Apo E-E3/3.There were no association between different gene types of Apo E and attempted suicide by conditional logistic regression analysis.Conclusion This study didn't support the association between Apo E gene and attempted suicide.There were different factors related with suicide attempters with different gene type of Apo E.