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| 新辅助化疗对乳腺癌细胞凋亡和增殖的影响 | |
| 引用本文： | 孟凡青 张琼 吕翔 周祀乔. 新辅助化疗对乳腺癌细胞凋亡和增殖的影响[J]. 临床肿瘤学杂志, 2005, 10(5): 515-517 |
| 作者姓名： | 孟凡青 张琼 吕翔 周祀乔 |
| 作者单位： | [1]南京大学附属鼓楼医院病理科,南京210008 [2]南京大学医学院,210008 |
| 基金项目： | 南京市科委资助项目（项目号：99716） |
| 摘 要： | 目的：观察乳腺癌新辅助化疗后癌细胞凋亡及增殖程度的变化,判断化疗疗效.方法：新辅助化疗手术标本44例和术前未接受化疗的对照组37例,进行Ki67及PCNA免疫组织化学染色和TUNEL原位细胞凋亡检测,并进行统计学处理.结果：化疗组Ki67、PCNA和AI的阳性细胞数比率分别为11.8%、31.3%和69.8%,对照组分别为21.6%、62.8%和52.8%,化疗组和对照组相比均有显著性差异.结论：新辅助化疗能抑制乳腺癌细胞的增殖,诱导凋亡. |
| 关 键 词： | 乳腺癌 新辅助化疗 细胞凋亡 增殖 |
| 文章编号： | 1009-0460(2005)05-0515-03 |
| 收稿时间： | 2005-01-26 |
| 修稿时间： | 2005-03-22 |
Effects of neoadjuvant chemotherapy on apoptosis and proliferation of breast cancer |
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| MENG Fan-qing, ZHANG Qiong, LV Xiang,ZHOU Si-qiao.. Effects of neoadjuvant chemotherapy on apoptosis and proliferation of breast cancer[J]. Chinese Clinical Oncology, 2005, 10(5): 515-517 | |
| Authors: | MENG Fan-qing ZHANG Qiong LV Xiang ZHOU Si-qiao. |
| Affiliation: | Department of Pathology, The Affiliated Drum Tower Hospital, Nanjing University Medical College, Nanjing 210008, China |
| Abstract: | Objective:To observe the change of the apoptosis level and proliferate degree of breast carcinomas after preoperative chemotherapy.Methods:Immunohistochemical labeling performed with the Ki67 and PCNA monoclonal antibodies, and TUNEL (terminal-deoxynucleotidyl transferase mediated d-UTP nick end labeling) were used.Results:The expressions of Ki67, PCNA in preoperative groups (11.8%, 31.3%) were significantly lower than those in control groups (21.6%, 62.8%). Apoptosis index of preoperative group (69.8%) was higher than that in control group (52.8%).Conclusion:The study showed neoadjuvant chemotherapy inhibited the proliferatation of breast cancer cell and induced apoptosis. |
| Keywords: | Breast cancer Neoadjuvant chemotherapy Apoptosis Proliferation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |