Evaluation in man of bumetanide,a new diuretic agent

Summary Bumetanide, a new diuretic, has been studied in ten healthy volunteers, who received single oral doses of 0.125 to 1.50 mg. It was potent and had, a rapid action; the maximum effect occurred within 60 to 90 min and lasted for 5 to 6 h. Within 60–90 min of a 1 mg dose the urine volume increased from 1 to about 10 ml/min and sodium excretion from about 100 µEq/min to about 1000 µEq/min. There was only a slight increase in potassium excretion. The mean total urinary volume during the first six hours after 1 mg of bumetanide was approximately 1500 ml. The increase of diuresis and saluresis after 0.125 mg was slight. In the dosage range of 0.125 to 1.0 mg there was a linear relationship between dose and increase in urinary volume and sodium excretion. Increasing the dose from 1.0 to 1.5 mg did not produce a correspondingly larger diuresis. The optimal range of doses of bumetanide appears to lie between 0.25 to 1.00 mg, according to the present results obtained in ten healthy volunteers.