乙酰肝素酶在肝细胞癌及胃癌中的表达及其临床意义

目的:探讨乙酰肝素酶(heparanase,HPSE)在肝细胞癌(hepatocellular carcinoma,HCC)及胃癌中的表达及其临床意义。方法:应用免疫组化法检测63例HCC组织及20例正常肝组织,81例胃癌组织及20例正常胃组织中HPSE的表达,并将检测结果与临床病理特征进行综合分析。结果:63例HCC组织及81例胃癌组织中HPSE表达率分别为61.9%(39/63)、56.8%(46/81),正常肝组织及胃组织均无HPSE表达。HCC组HPSE的表达与患者的性别、年龄、肿瘤大小、分化程度、甲胎蛋白(AFP)值均无显著相关性(P>0.05),胃癌组HPSE的表达与患者的性别、年龄、肿瘤大小、肿瘤部位、分化程度、浸润深度均无显著相关性(P>0.05),而两组HPSE表达与临床分期及淋巴结转移有显著相关性(P<0.05)。结论:HPSE在HCC及胃癌中表达率较高,HPSE表达与HCC及胃癌的临床分期及淋巴结转移有关,检测HPSE的表达情况对于判断恶性肿瘤的转移有重要价值。

Expressions and clinical significances of heparanase in hepatocellular carcinoma and gastric carcinoma

Objective To explore the expressions and clinical significances of heparanase(HPSE) in hepatocellular carcinoma(HCC) and gastric carcinoma.Methods The expressions of HPSE in 63 cases of HCC tissue,20 cases of normal hepatic tissue,81 cases of gastric carcinoma tissue,and 20 cases of normal gastric tissue were detected by immunohistochemical method,then the results were generally analyzed combined with clinicopathological features.Results The expression rates of HPSE were 61.9% in HCC tissue,56.8% in gastric...