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| 进口去羟肌苷肠溶胶囊在中国健康男青年体内药物动力学研究 | |
| 引用本文： | 赵红卫,秦玉花,张伟,丁祖锐,赵钰敏,张逸凡. 进口去羟肌苷肠溶胶囊在中国健康男青年体内药物动力学研究[J]. 实用诊断与治疗杂志, 2010, 24(1) |
| 作者姓名： | 赵红卫 秦玉花 张伟 丁祖锐 赵钰敏 张逸凡 |
| 作者单位： | 1. 河南省人民医院药剂科,郑州市,450003 2. 上海药物代谢研究中心 |
| 基金项目： | 河南省医学科技攻关工程资助项目 |
| 摘 要： | 目的:探讨进口去羟肌苷肠溶胶囊在中国健康男青年体内的药物动力学。方法:18例健康志愿者分别单剂量口服250mg去羟肌苷肠溶胶囊后按试验方案采血,用液相色谱-串联质谱法测定血药浓度,DAS2.0程序计算药物动力学参数。结果:健康受试者单剂量给药250mg后去羟肌苷的体内过程符合二室模型,主要药物动力学参数分别为tmax(1.7±1.0)h,Cmax(604.6±415.1)μg/L,AUC0-t(1381.8±670.0)μg.h/L,AUC0-∞(1408.3±672.7)μg.h/L,t1/2(1.7±0.3)h,Vd(629.4±622.7)L,CL(252.6±206.9)L/h。结论:进口去羟肌苷肠溶胶囊吸收较片、分散片和散剂为慢,但主要药物动力学参数与其他剂型相近。 |
| 关 键 词： | 药物动力学 去羟肌苷 肠溶胶囊 液相色谱-串联质谱 |
Pharmacokinetics of imported didanosine enteric capsules in healthy Chinese young men |
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| Abstract: | Objective To study the pharmacokinetics of imported didanosine enteric capsules in healthy Chinese young men. Methods Eighteen healthy volunteers were administrated with single dose of didanosine enteric capsules 250 mg. Blood was collected according to the protocol and the plasma concentrations of didanosine were measured with validated liquid chromatography-tandem mass spectrometry. Using DAS2.0 pharmacokinetic program,pharmacokinetic parameters were calculated on personal computer. Results The main pharm... |
| Keywords: | Pharmacokinetics didanosine enteric capsules liquid chromatography-tandem mass spectrometry |
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