| 血管紧张素原基因M235T分子变异与2型糖尿病肾病的关系 |
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| 引用本文： | 王健军,朱席琳,杨凌. 血管紧张素原基因M235T分子变异与2型糖尿病肾病的关系[J]. 中华医学遗传学杂志, 1999, 16(5) |
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| 作者姓名： | 王健军 朱席琳 杨凌 |
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| 摘 要： | 目的 探讨血管紧张素原（ａｎｇｉｏｔｅｎｓｉｎｏｇｅｎ ， Ａ Ｇ Ｔ） 基因 Ｍ２３５ Ｔ 分子变异与中国人无肾病并发症的２ 型糖尿病（ｄｉａｂｅｔｅｓ ｍ ｅｌｌｉｔｕｓ ， Ｄ Ｍ） 、２ 型糖尿病肾病（ｄｉａｂｅｔｉｃ ｎｅｐｈｒｏｐａｔｈｙ ， Ｄ Ｎ） 的关系。方法 用 Ｐ Ｃ Ｒ及 Ｒ Ｆ Ｌ Ｐ 方法对８４ 例 Ｄ Ｍ、９６ 例 Ｄ Ｎ 及９８ 名正常对照进行了 Ａ Ｇ Ｔ 基因 Ｍ２３５ Ｔ 多态性的检测。结果 Ｄ Ｎ 组 Ｔ 等位基因频率０８２ ， Ｔ Ｔ 基因型频率０７０ ，与对照组（０６３ ，０４３） 比较有显著差异（ Ｐ＝ ０００３ ， Ｐ＝００００４） ；校正了 Ｄ Ｎ 的几种危险因素后， Ｔ Ｔ 基因型对 Ｄ Ｎ 的 Ｏ Ｒ 为３４７（９５ ％ Ｃ Ｉ 为１５１ ～７９４ ， Ｐ＝０００３３） 。 Ｄ Ｍ 组基因型频率分布与对照组比较无显著差异（ Ｐ＞ ００５） 。结论 Ａ Ｇ Ｔ 基因 Ｔ Ｔ 型可能是中国人群２ 型糖尿病肾病的独立危险因素之一。
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| 关 键 词： | 血管紧张素原 基因 糖尿病肾病 2型糖尿病 多聚酶链式反应 |
Relationships of angiotensinogen gene M235T variant with diabetic nephropathy in Chinese type 2 diabetes mellitus |
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| WANG Jianjun ,ZHU Xilin,YANG Ling,ZHOU Wenyu,LI Hongbing,FU Hanqin,ZHU Liangxiang,YUAN Shenyuan. Relationships of angiotensinogen gene M235T variant with diabetic nephropathy in Chinese type 2 diabetes mellitus[J]. Chinese journal of medical genetics, 1999, 16(5) |
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| Authors: | WANG Jianjun ZHU Xilin YANG Ling ZHOU Wenyu LI Hongbing FU Hanqin ZHU Liangxiang YUAN Shenyuan |
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| Affiliation: | WANG Jianjun *,ZHU Xilin,YANG Ling,ZHOU Wenyu,LI Hongbing,FU Hanqin,ZHU Liangxiang,YUAN Shenyuan.*Department of Endocrinology,Affiliated Beijing Tongren Hospital,Capital University of Medical Sciences,Beijing 100730 P.R.China. E mail:Sunwj@publ |
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| Abstract: | Objective To investigate whether angiotensinogen (AGT) gene M235T variant is associated with type 2 diabetes mellitus without nephropathy(DM) and/or diabetic nephropathy(DN) in Chinese type 2 diabetes.Methods AGT genotypes of 84 cases with DM, 96 with DN and 98 controls were determined by polymerase chain reaction(PCR) amplification and restriction fragment length polymorphism analysis of the region of the variant.Results Increased frequencies of T allele(0.82) and TT genotype (0.70) were observed in 96 subjects with DN, compared with those observed in 98 control subjects (0.63 and 0.43 respectively, P =0.003, P =0.0004).The odds ratio associated with TT genotype was 3.47(95% CI 1.51 7.94, P =0.0033) for DN in analysis adjusted for several DN risk factors. There was no difference in allele distribution between 84 DM patients and the contorls.Conclusion TT genotype of the AGT gene might be an independent risk factor of diabetic nephropathy in Chinese patients with type 2 diabetes mellitus. |
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| Keywords: | Angiotensinogen Gene Diabetic nephropathy Type 2 diabetes mellitus Polymerase chain reaction |
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