| 小儿传染性单核细胞增多症患者外周血CD45RO＋、CD45RA＋T淋巴细胞亚群表达的研究 |
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| 引用本文： | 陈正平,王志琴. 小儿传染性单核细胞增多症患者外周血CD45RO＋、CD45RA＋T淋巴细胞亚群表达的研究[J]. 昆明医学院学报, 2011, 32(3): 38-40 |
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| 作者姓名： | 陈正平 王志琴 |
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| 作者单位： | 1. 昭通市妇幼保健院,云南,昭通,657000
2. 昭通市第一人民医院,云南,昭通,657000 |
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| 摘 要： | 目的探讨传染性单核细胞增多症（IM）患儿CD4＋T辅助淋巴细胞CD4＋CD45RO＋和CD4＋CD45RA＋T淋巴细胞亚群的变化.方法用流式细胞术检测了30例活动期IM、急性期及恢复期患者CD4＋T辅助细胞CD45RO、CD45RA的表达率,并与对照组进行了比较.结果 IM患者急性期与对照组相比CD4＋CD45RO＋明显增高（P〈0.05）,CD4＋CD45RA＋明显对低于对照组（P〈0.05）;恢复期CD4＋CD45RO＋与急性期比较明显降低（P〈0.05）,但仍高于正常对照组（P〈0.05）;CD4＋CD45RA＋与急性期相比明显升高（P〈0.05）,但仍低于对照组（P〈0.05）.结论 CD4＋CD45RO＋和CD4＋CD45RA＋T淋巴细胞在IM患者的细胞免疫中起重要作用,CD45RA＋T辅助细胞减少是导致机体免疫功能失去平衡的重要原因.
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| 关 键 词： | 传染性单核细胞增多症 CD45RO CD45RA 流式细胞术 |
Study on the Expression of CD45RO+ and CD45RA+T Lymphocytes in Peripheral Blood of Children Patients with Infectious Mononucleosis |
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| CHEN Zheng-ping,WANG Zhi-qin. Study on the Expression of CD45RO+ and CD45RA+T Lymphocytes in Peripheral Blood of Children Patients with Infectious Mononucleosis[J]. Journal of Kunming Medical College, 2011, 32(3): 38-40 |
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| Authors: | CHEN Zheng-ping WANG Zhi-qin |
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| Affiliation: | CHEN Zheng-ping1),WANG Zhi-qin2)(1)Maternal and Children Hospital of Zhaotong,Zhaotong Yunnan 657000,2)The 1st People's Hospital of Zhaotong,China) |
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| Abstract: | Objective To study the changes of CD45RO+ and CD45RA+T lymphocytess in peripheral blood in children with infectious mononucleosis.Method The expression of CD45RO+ and CD45RA+T lymphocytess in peripheral blood of children patients and controls was detected by flow cytometry.Results Compared with the control,the expression of CD4+CD45RO+ T lymphocytess in children with infectious mononucleosis in acute stage obviously increased(P<0.05),but the expression of CD4+CD45RA+ T lymphocytes was lower(P<0.05).The expr... |
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| Keywords: | CD45RO CD45RA |
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