| 脂肪细胞因子在肝纤维化进展中的作用及机制 |
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| 引用本文： | 霍新梅,黄会芳.脂肪细胞因子在肝纤维化进展中的作用及机制[J].临床肝胆病杂志,2019,35(3):644-647. |
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| 作者姓名： | 霍新梅 黄会芳 |
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| 作者单位： | 山西医科大学,太原,030001;山西医科大学第一医院消化内科,太原,030001 |
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| 摘 要： | 肝纤维化是肝硬化发生发展过程的必经阶段,不加控制的肝纤维化最终可导致肝硬化和(或)肝细胞癌。肝纤维化是一个动态过程,受多种因素调控。越来越多的证据表明,脂肪因子在肝脏中传递动态功能,并参与调节肝纤维化。就目前国内外学者对参与肝纤维化的脂联素、瘦素等一些主要脂肪细胞因子的研究,以及这些脂肪细胞因子在肝纤维化中作用机制的最新进展进行了综述。
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| 关 键 词： | 肝硬化 脂肪因子类 综述 |
Role and mechanism of action of adipocytokines in the progression of liver fibrosis |
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| HUO Xinmei,HUANG Huifang.Role and mechanism of action of adipocytokines in the progression of liver fibrosis[J].Chinese Journal of Clinical Hepatology,2019,35(3):644-647. |
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| Authors: | HUO Xinmei HUANG Huifang |
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| Institution: | (Shanxi Medical University, Taiyuan 030001, China) |
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| Abstract: | Liver fibrosis is an essential stage in the development and progression of liver cirrhosis, and uncontrolled liver fibrosis may eventually lead to liver cirrhosis and/or hepatocellular carcinoma. Liver fibrosis is a dynamic process regulated by many factors. An increasing number of evidence has shown that adipokines transmit dynamic functions in the liver and are involved in the regulation of liver fibrosis. This article reviews the research on major adipocytokines (adiponectin and leptin) involved in liver fibrosis and the recent advances in the mechanism of action of these adipocytokines in liver fibrosis. |
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| Keywords: | liver cirrhosis adipokines review |
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