2型糖尿病患者中性粒细胞/淋巴细胞比值与振动感觉阈值的相关性研究

目的探讨2型糖尿病(T2DM)患者中性粒细胞/淋巴细胞比值(NLR)与振动感觉阈值(VPT)之间的相关性。方法纳入在我院住院的T2DM患者965例,根据VPT将其分为振动觉正常组(A组,525例)、振动觉减退组(B组,265例)及振动觉缺失组(C组,175例),收集3组患者的年龄、病程、BM1、收缩压(SBP)、舒张压(DBP)、糖化血红蛋白(HbAlc)、ALT、血肌酐(Scr)、 WBC、中性粒细胞(NEU)、淋巴细胞(LYM)计数、NLR和VPT并进行比较比较,采用Spearrnm相关分析和Stepwise多元逐步回归分析评价NLR与VPT的相关性。结果与A组比较,B组和C组患者的年龄、病程和Scr明显增加(P均<0. 01);C组患者的NEU计数和NLR明显升高,LYM计数明显降低(P均<0.05)。Spearman相关分析结果显示,年龄(r=0. 425,P<0. 001)、病程(r=0. 227,P <0.001)、Scr( r =0. 147 ,P <0.001)、NLR( r =0.105,P<0.001)与 VPT 呈明显正相关,DBP( r=-0.087,P = 0.007).ALT(r=-0. 101,P=0.003)及 LYM(r=-0. 126,P <0.001)与 VPT 呈明显负相关。Stepwise多元逐步回归分析结果显示,年龄、病程、HbAlc、Scr和NLR是VPT的独立危险因素(P

Correlation between neutrophil-to-lymphocyte ratio and vibration perception threshold in patients with type 2 diabetes mellitus

Objective To explore the correlation between neutrophil-to-lymphocyte ratio( NLR) and vibration perception threshold ( VPT) in patients with type 2 diabetes mellitus ( T2DM ). Methods 965 T2DM patients in our hospital were enrolled and divided into 3 groups, the vibration sensation normal group(group A, 525 cases), the vibration sensation hypoesthesia group ( group B, 265 cases) and the vibration sensation deficiency group(group C, 175 cases) according to VPT. Age,course of disease,body mass index( BMI), systolic pressure ( SBP), diastole pressure ( DBP), hemoglobin Ale ( HbAlc ), ALT, serum creatinine ( Scr ), WBC, Neutrophil ( NEU ), lymphocyte ( LYM ) counts, NLR and VPT were collected and compared. The correlation between NLR and VPT was evaluated by Spearman correlation analysis and multiple stepwise regression analysis. Results Compared with group A, age, course of disease and Scr in group B and C increased significantly ( P < 0. 01);NEU and NLR increased significantly and LYM decreased significantly in group C ( P < 0. 05 ). Spearman correlation analysis showed that age (r = 0.425 , P v0. 001 ),course of disease ( r = 0. 227, P < 0. 001 ), Scr ( r = 0. 147, P <0. 001 ) and NLR (r = 0. 105 , P <0. 001 ) were positively correlated with VPT. DBP ( r = 0. 087 , P =0. 007 ), ALT(r =-0. 101, P = 0.003) and LYM(r =-0. 126, P <0. 001) were negatively correlated with VPT. Multiple stepwise regression analysis showed that age, course of disease, HbAlc, Scr and NLR were independent risk factors for VPT. Conclusion NLR is positively correlated with VPT and is an independent risk factor for VPT. NLR may be involved in the occurrence and development of DPN.