微生态调节剂对初诊系统性红斑狼疮患者的干预治疗作用

目的探讨微生态调节剂对初诊系统性红斑狼疮(SLE)患者的干预治疗作用。方法将80例初诊SLE患者随机分为对照组40例和观察组40例。两组患者均给予SLE的规范治疗,同时观察组加用双歧杆菌乳杆菌三联活菌片。采用SLE疾病活动指数(SLEDAI)评分评估患者疾病活动程度。分别于治疗前及治疗12周后检测两组患者的血常规、红细胞沉降率(ESR)、IgA、IgG、补体C3、补体C4、ALT、AST、血肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白及粪便球杆比并进行比较。结果治疗前两组患者各项指标比较差异均无统计学意义(P>0.05).治疗后两组患者ESR、IgA、IgG、ALT、AST、Scr、BUN水平均低于同组治疗前,补体C3、C4水平均高于同组治疗前,观察组治疗后粪便球杆比低于治疗前(P<0.05)。对照组治疗前后WBC计数、Hb、PLT计数、粪便球杆比及观察组治疗前后WBC计数、Hb、PLT计数比较,差异均无统计学意义(P > 0.05)。治疗后观察组患者IgA、IgG、AST水平、粪便球杆比、SLEDAI评分及24 h尿蛋白均低于对照组,补体C3水平高于对照组(P<0.05)。结论微生态调节剂干预治疗后,初诊SLE患者机体炎症及免疫反应被抑制、尿蛋白减少,并发消化系统症状少,且微生态调节剂的肝肾不良反应小,较为安全有效。

Effect of microecologics on the treatment of newly diagnosed systemic lupus erythematosus

Objective To explore the effect of microecologics on treatment of newly diagnosed systemic lupus erythematosus( SLE). Methods Eighty patients with newly diagnosed SLE were randomly divided into control group(40 cases) and observation group(40 cases). Patients in two groups were all given standardized treatment of SLE, and patients in observation group were supplemented with bifidobacterium bifidum triple live bacteria tablets. SLE disease activity index( SLEDAI) score was used to assess the extent of disease activity of newly diagnosed SLE patients. Blood routine, erythrocyte sedimentation rate ( ESR), IgA, IgG, complement C3 , C4, ALT, AST, serum creatinine( Scr), urea nitrogen( BUN),24 h urine protein and fecal microflora abnormal rate were measured before treatment and 12 weeks after treatment. Results There were no significant differences of all indexes between the two groups before treament ( P > 0. 05 ). ESR,IgA, IgG, ALT, AST, Scr and BUN levels after treatment in two groups were all lower than those in the same group before treatment, complement C3 and C4 levels were higher than those in the same group before treatment, and fecal microflora abnormal rate after treatment was lower than that before treatment in observation group( P <0. 05 ). There were no significant differences of WBC count, Hb, PLT count, fecal microflora abnormal rate before and after treatment in control group and WBC count, Hb, PLT count before and after treatment in observation group(P >0. 05 ). IgA,IgG, AST level,fecal microflora abnormal rate, SLEDAI score and 24 h urine protein were lower in observation group than those in control group after treatment,and complement C3 level was higher than that in control group (P <0. 05). Conclusion After intervention of microecologics, the inflammation and immune response of newly diagnosed SLE patients are inhibited, urinary protein is reduced, and the digestive system symptoms are less. Liver and kidney adverse reactions of microecologics are small which shows microecologics is safe and effective for newly diagnosed.