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Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis |
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| Authors: | Natalie Hecht Abiodun Omoloja Dave Witte Leonardo Canessa |
| Affiliation: | (1) Department of Pediatrics, Wright State University Boonshoft School of Medicine, Dayton, OH, USA;(2) Department of Pathology, University of Cincinnati, Cincinnati, OH, USA;(3) Department of Nephrology, The Children’s Medical Center, One Children’s Plaza, Dayton, OH 45404, USA |
| Abstract: | Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare disease characterized by autoantibodies to the alpha 3 chain of type IV collagen in the GBM. It is also known as Goodpasture’s syndrome when associated with pulmonary hemorrhage due to autoantibodies to the alpha 3 chain of type IV collagen also present in pulmonary alveoli. Even more rare is the evolution of anti-GBM GN into membranous nephropathy (MN). We report the management of a 9-year-old Caucasian girl with anti-GBM GN that evolved into MN and briefly review the literature. |
| Keywords: | Anti-GBM antibody Membranous glomerulonephritis |
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