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Reversal of rocuronium-induced (1.2 mg kg-1) profound neuromuscular block by accidental high dose of sugammadex (40 mg kg-1)
Authors:Molina A L  de Boer H D  Klimek M  Heeringa M  Klein J
Affiliation:1 Department of Anaesthesiology, Erasmus University Medical Centre, Rotterdam, The Netherlands
2 Department of Anaesthesiology, Radboud University Medical Centre Nijmegen, Martini Hospital Groningen, The Netherlands
3 Global Clinical Development, NV Organon, Oss, The Netherlands
Abstract:
Sugammadex is the first selective relaxant binding agent andreverses rocuronium-induced neuromuscular block. A case is reportedin which a patient accidentally received a high dose of sugammadex(40 mg kg–1) to reverse a rocuronium-induced (1.2 mg kg–1)profound neuromuscular block. A fast and efficient recoveryfrom profound neuromuscular block was achieved and no adverseevents or other safety concerns were reported.
Keywords:neuromuscular block, rocuronium   neuromuscular relaxant, sugammadex   reversal agent
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