慢性荨麻疹患者血清中Ｄ-二聚体水平和IL-33表达及意义

 目的:探讨慢性荨麻疹（CU）患者血清中D-二聚体水平和 IL-33的水平及其临床意义。方法:将63例CU患者依据自身血清皮肤试验（ASST）结果进行分组，取同期体检健康者作为对照组，采用ELISA法检测三组患者血清中D-二聚体水平和 IL-33水平并进行比较。结果:63例CU患者中，37例ASST阳性（58.73%），26例阴性（41.27%）。相比对照组D-二聚体水平［2.437 ±0.120） mg/L］，ASST（+）组 ［（25.797±7.756） mg/L］和ASST（-）组［（30.605±9.101）mg/L］均明显增加（t值分别为10.25、10.58，P值均<0.05），但ASST（-）组与ASST（+）组两组间无明显差异（t=1.39, P＞0.05）。ASST（+）组血清中IL-33含量 ［（0.237±0.037） pg/mL］明显高于对照组［（0.069±0.001） pg/mL］，t=7.78，P<0.05，而ASST（-）组IL-33水平［（0.112±0.028） pg/mL］无明显变化（t=2.63, P＞0.05），ASST（-）和ASST（+）间有明显差异（t=4.69, P<0.05）。结论:CU患者血清中D-二聚体水平及ASST（+）组IL-33水平升高，可能导致机体免疫系统失衡，在CU的发生与发展中发挥一定作用。

Serum D-dimer and IL-33 in patients with chronic urticaria

Objective：To explore the levels and clinical characteristics of serum D dimer and IL-33 in patients with chronic urticaria.  Methods: A total of 63 patients with chronic urticarial were  divided into a  positive  group  and  a negative  group according to the results of the autologous serum skin test, in addition,  a normal control group was set. The levels of serum D dimer and IL-33 were measured by ELISA in all three groups. Results: Of the 63 patients with chronic urticaria, 37 were positive for ASST, 26 were negative for ASST．Serum levels of D dimer and IL-33 in patients with chronic urticaria of the positive group were significantly higher than that in normal controls (all P<0.05). There was no significant difference in D-dimer level between the positive group and negative group (P＞0.05). Conclusion: The levels of D-dimer are high in patients with chronic urticaria, the levels of IL-33 are high in positive  group, and these elevated D-dimer and IL-33 may lead to the imbalance of the immune system and increase the occurrence and development of chronic urticaria.