心肌梗死患者血管紧张素原基因T174突变检测的临床意义

目的探讨血管紧张素原基因(AGT)T174在人群中的分布、与临床心肌梗死的相关性。方法对入选的心肌梗死患者组及健康对照组,用聚合酶链反应(PCR)、限制性片段长度多态性(RFLP)分析,对群体患者和群体健康对照组进行基因分型,统计分析。结果 AGT基因型频率及等位基因频率分布比较均匀;心肌梗死发生与民族、性别、年龄无特异相关性。174MM型和M 174等位基因的频率患者组显著高于健康对照组,携带突变型MM基因型的个体比野生型TT者患心肌梗死的危险性高5.667倍,基因突变与心肌梗死发生相关。结论 AGT基因基因型及等位基因在群体中的分布无民族、年龄、性别差异,MM基因型与心肌梗死有关。

Angiotensinogen gene T174 mutation detection and clinical significance of myocardial infarction

Objective Explore the angiotensinogen（AGT） gene T174 in the population distribution, and clinical relevance of myocardial infarction. Methods For selected patients with myocardial infarction group and healthy controls, using polymerase chain reaction, restriction fragment length polymorphism analysis, the patient population group and the group of healthy control group genotyping, statistical analysis. Results AGT genotype and allele frequency distribution more uniform; myocardial infarction and ethnic, gender, age, non-specific relevance. The frequency of ACT 174MM and the allele of M174 are significantly higher in AMI patients than those in the healthy control group. The AMI risks of individuals carrying mutational MM gene were 5. 667 higher than those of TT gene of natural type,showing that there was relevance between gene mutation and the occurrence of AMI. Conclusion There was no age and sex difference between AGT gene type and the equivalent gene among the group of people of Han nationality; the MM gene of AGT gene was relevant to Acute myocardial infarction.