正常成人子宫超声造影表现分析

目的 探讨正常育龄妇女子宫超声造影增强特点.方法 应用超声造影及定量分析技术对41名健康育龄妇女正常子宫进行超声造影检查及时间-强度曲线定量分析,检测参数为子宫肌层、子宫内膜和宫颈肌层的超声造影剂到达时间(AT)、达峰时间(TTP)、峰值强度(PI).结果 实时超声造影可清晰显示子宫内造影剂的增强过程,造影剂呈向心性由子宫周边向中央增强,子宫前后壁肌层及宫颈同步增强,随后子宫内膜开始增强.消退顺序与之相反,即子宫内膜先消退,子宫肌层及宫颈同步随后消退.时间-强度曲线定量分析结果显示:正常女性子宫肌层、宫颈和子宫内膜的AT分别为(12.08±2.08)s、(11.98±1.91)s和(16.54±2.48)s;TTP分别为(20.64±3.10)s、(21.48±2.93)s和(24.86±3.71)s;PI分别为(28.20±5.54)、(26.38±5.70)和(24.21±7.35).子宫肌层及宫颈与子宫内膜AT、TTP的差异有统计学意义(t=8.249、8.422、4.691、5.861,P均<0.01);子宫肌层与子宫内膜PI差异有统计学意义(t=1.656,P=0.024),3组间其他参数比较差异无统计学意义(t=0.173、1.170、1.944、3.600,P均>0.05).结论 超声造影能较好显示正常成人子宫的血流灌注特点,可为进一步研究子宫相关疾病提供依据.

The analysis of normal women uterus appearance imaging using contrast-enhanced ultrasound

Objective To discuss the uterus blood perfusion characteristics of normal women of child-bearing age.Methods Forty-one cases were examined with real-time contrast-enhanced ultrasound（CEUS）and the perfusion process was observed.The contrast agent was given intravenously,the perfusion analysis of the myometrium,cervix and endometrium was performed.The time-intensity curves in the three parts were analyzed by a quantification software.Results CEUS clearly showed the enhancement of contrast agent within the uterus：the contrast washed in from peripheral to the central part of uterus,the uterine anterior and posterior wall and cervix appeared synchronous enhancement,the endometrium enhanced later.The washing out mode of perfusion of uterus appeared contrarily：the contrast in endometrium washed out more quickly than that in myometrium and cervix.The quantitative analysis of the time-intensity curves showed that：The arrival time for the myometrium,cervix and endometrium were（12.08±2.08）s,（11.98±1.91）s and（16.54±2.48）s,respectively.The peak time for the myometrium,cervix and endometrium were（20.64±3.10）s,（21.48±2.93）s and（24.86±3.71）s,respectively.The peak intensity for the myometrium,cervix and endometrium were（28.20±5.5）,（26.38±5.70）and（24.21±7.35）respectively.The value of AT and TTP had significantly statistical differences between myometrium,cervix and endometrial（t=8.249,8.422,4.691,5.861,P0.01）.There were significant statistical differences in the peak intensity between myometrium and endometrial（t=1.656,P=0.024）.No significant differences were found in the other parameters among the three groups（t=0.173,1.170,1.944,3.600,all P0.05）.Conclusion CEUS successfully displayed the normal characteristics of adult uterine perfusion,the preliminary results of the study provides quantitative parameters,which could be helpful for the further research of uterus disease.