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Cerebral net exchange of large neutral amino acids after lipopolysaccharide infusion in healthy humans |
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| Authors: | Ronan MG Berg Sarah Taudorf Damian M Bailey Carsten Lundby Fin Stolze Larsen Bente Klarlund Pedersen Kirsten Møller |
| Affiliation: | (1) Department of Infectious Diseases, Rigshospitalet, Centre of Inflammation and Metabolism, Blegdamsvej 9, 2100 Copenhagen, Denmark;(2) Neurovascular Research Laboratory, Faculty of Health, Science and Sport, University of Glamorgan, CF37 1DL Pontypridd, South Wales, UK;(3) Copenhagen Muscle Research Centre, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark;(4) Department of Hepatology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark;(5) Department of Cardiothoracic Anaesthesia and Intensive Care Unit 4131, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark |
| Abstract: | IntroductionAlterations in circulating large neutral amino acids (LNAAs), leading to a decrease in the plasma ratio between branched-chain and aromatic amino acids (BCAA/AAA ratio), may be involved in sepsis-associated encephalopathy. We hypothesised that a decrease in the BCAA/AAA ratio occurs along with a net cerebral influx of the neurotoxic AAA phenylalanine in a human experimental model of systemic inflammation. |
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