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Management of degenerative disk disease and chronic low back pain |
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| Authors: | Karppinen Jaro Shen Francis H Luk Keith D K Andersson Gunnar B J Cheung Kenneth M C Samartzis Dino |
| Affiliation: | aInstitute of Clinical Sciences, Department of Physical and Rehabilitation Medicine, University of Oulu, Box 5000, Oulu 90014, Finland;bDepartment of Orthopaedic Surgery, University of Virginia, 400 Ray C. Hunt Drive, Suite 330, Charlottesville, VA 22908, USA;cDepartment of Orthopaedics and Traumatology, Division of Spine Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Professorial Block, 5th Floor, 102 Pokfulam Road, Pokfulam, Hong Kong SAR, China;dDepartment of Orthopaedic Surgery, Rush University Medical Center, 1611 West Harrison Street, Chicago, IL 60612, USA |
| Abstract: | Degenerative disk disease is a strong etiologic risk factor of chronic low back pain (LBP). A multidisciplinary approach to treatment is often warranted. Patient education, medication, and cognitive behavioral therapies are essential in the treatment of chronic LBP sufferers. Surgical intervention with a rehabilitation regime is sometimes advocated. Prognostic factors related to the outcome of different treatments include maladaptive pain coping and genetics. The identification of pain genes may assist in determining individuals susceptible to pain and in patient selection for appropriate therapy. Biologic therapies show promise, but clinical trials are needed before advocating their use in humans. |
| Keywords: | Disk Degeneration Chronic Low back Pain Conservative Surgery Genetic |
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