Lipidomics: New approaches to the studies of cell signaling and prospects of use in medicine |
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Authors: | T I Torkhovskaya E M Khalilov A A Korotaeva |
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Institution: | (1) Institute of Physicochemical Medicine, Federal Agency for Health Care and Social Development, Moscow |
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Abstract: | A new modern stage in the development of lipid biochemistry is presented: lipidomics, which emerged on the basic of new highly
sensitive fractionation methods, primarily, mass spectroscopy. Lipidomics is defined mainly as systemic evaluation of all
molecular types of lipids in an object, their cell functions, and molecules with which they react. Lipidomic approaches identifying
picomole levels of individual lipids in combination with modern genome technology provide detailed information about the involvement
of minor phospholipids in the cell signaling processes. Brief data on the functions of lysophospholipids as second messengers
of signal transfer, their effects on cell processes, and possible involvement in the pathogenesis of some diseases are presented.
It is expected that introduction of lipidomics in biomedical studies will promote the detection of targets for new drugs and
development of new diagnostic tests.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Supplement 2, pp. 33–38, April, 2007 |
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Keywords: | cell signaling lysosphingolipids lysophosphatide acid lipidomics |
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