伊托必利联合复方阿嗪米特治疗胆囊切除术后功能性消化不良的疗效分析

目的 对伊托必利片联合复方阿嗪米特肠溶片对胆囊切除术后功能性消化不良的临床疗效及安全性进行评价.方法 选择2009年12月至2012年12月在西安市第一医院消化内科就诊的既往有胆囊切除手术病史,临床上有消化不良症状的患者76例,采用区组随机化分为试验组（38例）和对照组（38例）,试验组给予伊托必利片和复方阿嗪米特肠溶片口服,对照组仅给予伊托必利片口服,疗程均为4周.采用临床症状积分法对两组患者治疗前后消化不良症状情况进行评估,并比较其治疗效果.结果 治疗4周后两组患者症状积分均较治疗前降低,比较差异有统计学意义（P＜0.05）,试验组症状积分改善率优于对照组,比较差异有统计学意义（P＜0.05）.两组患者治疗1周后疗效比较无统计学意义差异（Z=-1.11,P＞0.05）;但治疗2、3、4周后,试验组患者的疗效高于对照组,差异有统计学意义（Z=-3.95、-4.56、-4.93,P＜0.05）.结论 伊托必利片与复方阿嗪米特肠溶片联合应用治疗胆囊切除术后功能性消化不良的临床疗效显著优于单独应用伊托必利.

Clinical Analysis of Itopride Combined with Compound Azintamide for Treating Functional Dyspepsia after Cholecystectomy

Objective To evaluate the efficacy and safety of itopride combined with compound azin-tamide for treating functional dyspepsia after cholecystectomy. Methods From January 2009 to March 2012, 76 patients with functional indigestion after cholecystectomy in Xi＇an No. 1 Hospital were selectedand all the patients were divided into control group（ n = 38 ） and trial group（ n = 38 ） with randomized block design. The trial group was given itopride and azintamide, and the control group was only given itopride. The course of treatment was 4 weeks. The changes of functional dyspepsia symptoms were evaluated by clinical symptom score, and the clinical effects of the two groups were compared. Results The abdominal symptom scores of both groups were significantly lower than those, before treatment （ P 〈 0.05 ）. The improvement of abdominal symptom scores of the trial group were significantly higher than that of the control group（ P 〈 0.05 ）. The total effective rates after 1 week＇s treatment of the trial group and the control group had no statistical significance （ Z = - 1.11 ,P 〉 0. 05 ） ; however, the total effective rates after 2,3,4 week＇ s treatment of the trial group were significantly higher than that of the control group respectively （ Z = - 3.95, - 4. ：56, - 4.93, P 〈 0.05 ）. Conclusion Combined therapy of itopride and compound azintamide are significantly more effective than the single application of itopride for functional dyspepsia after gall bladder surgery.