| 参麦注射液对移植性肿瘤血管生成的影响 |
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| 引用本文： | 高承贤,丁志山,尹丽慧,方三华,袁巍,沃兴德.参麦注射液对移植性肿瘤血管生成的影响[J].中成药,2003,25(9):728-731. |
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| 作者姓名： | 高承贤 丁志山 尹丽慧 方三华 袁巍 沃兴德 |
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| 作者单位： | 浙江中医学院分子医学研究所,浙江,杭州,310053 |
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| 基金项目： | 浙江省自然科学基金 (No .3990 0 9)，浙江省中医管理局科研基金 (No .2 0 0 0C11)资助 |
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| 摘 要： | 目的：研究参麦注射液(红参，麦冬)对肿瘤组织内血管生成和细胞增殖核抗原表达的影响，探讨参麦抗肿瘤的机理。方法：通过建立小鼠移植性S180肿瘤模型，从整体水平上观察参麦对肿瘤生长的影响，并采用免疫组织化学方法，检测肿瘤组织中第Ⅶ因子相关抗原(vWF)和细胞增殖核抗原(PCNA)的表达。结果：参麦具有抑制肿瘤生长作用；参麦能降低肿瘤组织中微血管密度，能减少PCNA的表达。结论：抗血管生成是参麦抗肿瘤机理之一。
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| 关 键 词： | 参麦注射液 肿瘤 血管生成 微血管密度 细胞增殖核抗原 小鼠 |
| 文章编号： | 1001-1528(2003)09-0728-03 |
| 修稿时间： | 2002年6月18日 |
Effect of Shenmai Injection on angiogenesis in tumor tissue |
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| GAO Cheng xian,DING Zhi shan,YIN Li hui,FANG San hua,YUAN Wei,WO Xing de.Effect of Shenmai Injection on angiogenesis in tumor tissue[J].Chinese Traditional Patent Medicine,2003,25(9):728-731. |
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| Authors: | GAO Cheng xian DING Zhi shan YIN Li hui FANG San hua YUAN Wei WO Xing de |
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| Abstract: | Objective: To investigate the effect of Shenmai Injection (Radix Ginseng Rubra, Radix Ophiopogonis) on angiogenesis and the expression of proliferating cell nuclear antigen (PCNA) in tumor tissue, and the mechanism of it in the treatment of tumor. Methods: The mouse tumor model was used to investigate the effect of Shenmai Injection on tumor growth on the whole. The expression of von Willebrand factor (vWF) and PCNA in tumor tissue was studied by means of immunohistochemistry. Results: Shenmai inhibited the tumor growth and reduced microvessel density and the expression of PCNA in tumor tissue. Conclusion:Antiangiogenesis is one of the mechanisms of Shenmai Injection in treatment of tumor. |
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| Keywords: | Shenmai Injection tumor angiogenesis microvessel density proliferating cell nuclear antigen mouse |
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