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Granulocytic sarcoma: An atypical presentation in the oral cavity
Authors:Eric T. Stoopler DMD  res Pinto DMD    Faizan Alawi DDS    Sree Raghavendra DMD    Ricardo Boyce Jr. DDS    David Porter MD   Thomas P. Sollecito DMD
Affiliation:Assistant Professor of Oral Medicine, University of Pennsylvania School of Dental Medicine;Assistant Professor of Pathology, University of Pennsylvania School of Dental Medicine;Fellow, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine;Associate Professor of Medicine, University of Pennsylvania School of Medicine;Associate Professor of Oral Medicine, University of Pennsylvania School of Dental Medicine.
Abstract:Acute myelogenous leukemia (AMU is a hematologic disorder that is characterized by an abnormal proliferation of immature myeloid cells. Granulocytic sarcomas are clusters of leukemic myeloid cells that may develop as a result of AML. Oral manifestations of AML are common and often involve enlargements of the gingiva and/or mucosal tissue from direct leukemia cell infiltration. We describe the case history of a 50-year-old man who had an ulcera-tive lesion of the oral mucosa that was determined to be a granulocytic sarcoma of AML-M0 subtype. The combination of both the subtype and clinical presentation of the leukemia makes this presentation unusual, and to the best of our knowledge, of a type that has not been previously reported in the literature.
Keywords:acute myelogenous leukemia    granulocytic sarcoma
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