| Ets-1在子宫内膜癌中的表达及意义 |
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| 引用本文： | 郝长宏,田永会,刘正玲,许宗兰. Ets-1在子宫内膜癌中的表达及意义[J]. 现代妇产科进展, 2017, 0(6): 437-439. DOI: 10.13283/j.cnki.xdfckjz.2017.06.008 |
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| 作者姓名： | 郝长宏 田永会 刘正玲 许宗兰 |
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| 作者单位： | 山东省临沂市中心医院妇科,临沂,276400 |
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| 基金项目： | 山东省卫生厅基金(2014WS0290) |
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| 摘 要： | 目的:探讨Ets-1在子宫内膜癌组织中的表达及其与临床分期、病理分级、分型及预后的关系。方法:免疫组化SP法检测子宫内膜癌及正常子宫内膜组织中Ets-1表达,荧光原位杂交法检测Ets-1 mRNA表达。结果:子宫内膜癌组织中Ets-1蛋白阳性表达率为88.8%,高于正常子宫内膜。子宫内膜癌组织中Ets-1表达与临床病理分期、肌层浸润与病理分级有关,差异有统计学意义(P<0.05)。结论:Ets-1与子宫内膜癌的临床分期、病理分级、转移密切相关。
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| 关 键 词： | 子宫内膜癌 Ets-1 免疫组织化学 荧光原位杂交技术 |
The expression and clinical significance of Ets-1 in endometrial carcinoma |
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| Abstract: | Objective:To investigate the expression of Ets-1 in endometrial carcinoma tissues,the relationship between Ets-1 and clinical stage,pathological grading and typing of endometrial carcinoma.Methods:The expression of Ets-1 was detected in endometrial carcinoma and normal endometrium using imunohistochemical sp method and fluorescence in situ hybridization.Results:The positive expression of Ets-1 protein in endometrial carcinoma rate was 88.8%,was higher than normal endometrial tissue.The expression of Ets-1 in endometrial carcinoma was correlated with clinicopathological stage,muscular layer infiltration and pathological grading (P<0.05).Conclusion:Ets-1 is closely related to clinical stage,pathological grading and metastasis of endometrial carcinoma. |
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| Keywords: | Ets-1 protein Ets-1 mRNA Endometrial carcinoma Immunohistoche-mistry Fluorescent in situ hybridization method |
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