甲磺酸左氧氟沙星与左氧氟沙星临床验证比较

目的 :比较甲磺酸左氧氟沙星与左氧氟沙星治疗细菌性感染的有效性和安全性。方法 :采用随机对照试验将 12 6例细菌性感染病人分为甲磺酸左氧氟沙星组和左氧氟沙星组 ,其中甲磺酸左氧氟沙星组 6 3例 ,男性 30例 ,女性 33例 ,年龄 ( 41±s6 )a;左氧氟沙星组 6 3例 ,男性 36例 ,女性 2 7例 ,年龄 ( 40± 9)a。2组分别给予甲磺酸左氧氟沙星片和左氧氟沙星片各 10 0mg ,po,tid ,疗程 7～ 14d。结果 :2组临床总有效率分别为 89% ( 56 /6 3)和 84 %( 53/6 3) ,细菌清除率分别为 89%和 89% ,不良反应发生率分别为 2 1% ( 13/6 3)和 18% ( 11/6 3) ,经统计学处理均差异无显著意义 (P >0 .0 5)。结论 :甲磺酸左氧氟沙星和左氧氟沙星治疗细菌性感染安全、有效

Clinical verfication of levofloxacin mesylate vs levofloxacin

AIM: To compare the efficacy and safety of levofloxacin mesylate with levofloxacin in the treatment of bacterial infections. METHODS: A randomized controlled clinical trial was conducted. One hundred and twenty six patients with bacterial infections were divided into two groups. Levofloxacin mesylate groups sixty three patients, (M 30, F 33, age (41± s 6) a); Levofloxacin group sixty three patients, (M 36, F 27, age (40±9) a). The two groups were orally given levofloxacin mesylate or levofloxacin 100 mg, tid, for 7 14 d, respectively. RESULTS: The total clinical effective rates were 89% (56/63) in levofloxacin mesylate group and 84% (53/63) in levofloxacin group. The bacterial clearance rates were 89% and 89%. The adverse reaction rates were 21%(13/63) and 18%(11/63), respectively. There was no statistical significance between two groups ( P > 0.05 ). CONCLUSION: Levofloxacin mesylate and levofloxacin are effective and safe in the treatment of bacterials infections.