HBV相关慢加急性肝衰竭患者血清miRNA表达谱及临床预测价值

微小RNA（miRNAs）是一类内源性且具有精细调控功能的非编码单链RNA，能抑制靶基因的mRNAs翻译或引起其降解，与病毒发病机制和组织癌变的发生息息相关。乙型肝炎病毒（HBV）感染宿主后会发生肝炎、肝硬化、肝癌3步转归，而在该疾病发展过程中，HBV和宿主细胞利用miRNAs进行相互调节，期间伴有不同miRNAs表达谱的变化，并且以miRNAs作为新的抗HBV作用靶点开发抗病毒药物的前景良好，而很少有人对该领域的研究进行综述，因此本文就miRNAs在诊断和治疗HBV感染相关肝病的研究进展做一综述。

Alteration of microRNA profiles by a novel inhibitor of human La protein in HBV-transformed human hepatoma cells

MicroRNAs (miRNAs), as a kind of endogenous and stable non-coding single-stranded RNA with fine regulation function, can inhibit translation or degradation of their target genes and these processes correlate closely with the pathogenesis of some viruses and carcinogenesis of cells. During pathological processes of inflammation, cirrhosis, and canceration of liver in relation to hepatitis B virus (HBV) infection, miRNAs mediate mutual regulations between HBV and host cells and the expression spectrum of miRNAs varies with the ongoing of the mediations. These knowledge highlight good prospects in developing new antiviral agents targeted regulations of miRNAs. The study reviews published researches on applications of miRNAs in diagnosis and treatment of HBV infection related liver diseases.