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| 胰岛素对全血血小板膜P-选择素表达影响的研究 | |
| 引用本文： | 彭必友 周艳 董为人 汪吉仪 薛耀明 蔡德鸿. 胰岛素对全血血小板膜P-选择素表达影响的研究[J]. 第一军医大学学报, 2004, 24(12): 1434-1436 |
| 作者姓名： | 彭必友 周艳 董为人 汪吉仪 薛耀明 蔡德鸿 |
| 作者单位： | [1]广州市司法局东坑劳教所门诊部，广东广州510515 [2]白云区人民医院，广东广州510511 [3]南方医科大学组织胚胎学教研室，广东广州510515 [4]南方医科大学南方医院内分泌科，广东广州510515 [5]南方医科大学珠江医院内分泌科，广东广州510282 |
| 摘 要： | 目的探讨胰岛素对血小板膜P-选择素表达的影响。方法建议全血血小板膜P-选择素表达的流式细胞术(FCM)测定方法，观察健康青年人胰岛素在静止和活化状态下对血小板膜P-选择素表达的影响。结果胰岛素对正常人静息血小板膜P-选择素表达无明显影响；而显著抑制凝血酶、胶原活化的血小板膜P-选择素的上调表达，且该效应呈剂量和时间依赖性。结论胰岛素可抑制活化血小板膜P-选择素的表达。 |
| 关 键 词： | 胰岛素 P-选择素 流式细胞术 |
Effect of insulin on expression of whole-blood platelet membrane P-selectin] |
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| Bi-you Peng,Yan Zhou,Wei-ren Dong,Ji-yi Wang,Yao-ming Xue,De-hong Cai. Effect of insulin on expression of whole-blood platelet membrane P-selectin][J]. Journal of First Military Medical University, 2004, 24(12): 1434-1436 | |
| Authors: | Bi-you Peng Yan Zhou Wei-ren Dong Ji-yi Wang Yao-ming Xue De-hong Cai |
| Affiliation: | Clinic of Dongkeng Labor Reeducation Camp, Justice Bureau of Guangzhou, Guangzhou 510515, China. pengbiyou@fm365.com |
| Abstract: | OBJECTIVE: To investigate the effects of insulin on the expression of whole-blood platelet membrane P-selectin. METHODS: Flow cytometry (FCM) was used to detect the expression of whole-blood platelet membrane P-selectin, and the effect of insulin on the expression on quiescent and activated plasma platelet observed in normal young subjects. RESULTS: Insulin had no effect on the P-selectin expression on quiescent platelet membrane, but significantly inhibited the up-regulation of P-selectin expression induced by thrombin and collagen respectively, exhibiting dose- and time-dependent effects. CONCLUSION: Insulin can inhibit P-selectin expression on activated platelet membrane. |
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